Stack M J, Scott A C, Done S H, Dawson M
Central Veterinary Laboratory, New Haw, Weybridge, Surrey.
Vet Rec. 1991 Jun 8;128(23):539-40. doi: 10.1136/vr.128.23.539.
Extracts from the cervical spinal cord and from the medulla, thalamus, cerebellum and cerebral cortex of the brains of 10 sheep, histopathologically confirmed as cases of scrapie, were examined by electron microscopy for the presence of scrapie-associated fibrils. Characteristic fibrils were observed in all the extracts except for that from the thalamus of one sheep. No fibrils were found in any extracts from three control sheep. A comparison of these results with a similar study of 22 cases of bovine spongiform encephalopathy (BSE) suggests that in cases of scrapie the area of the brain chosen for the detection of fibrils is less critical than in cases of BSE, in which fibrils are more readily extracted from areas of the brain stem.
对10只经组织病理学确诊为羊瘙痒病的绵羊的颈脊髓以及脑的延髓、丘脑、小脑和大脑皮质提取物进行电子显微镜检查，以寻找瘙痒病相关纤维。除一只绵羊丘脑的提取物外，在所有提取物中均观察到特征性纤维。三只对照绵羊的任何提取物中均未发现纤维。将这些结果与对22例牛海绵状脑病（BSE）的类似研究进行比较表明，在瘙痒病病例中，选择用于检测纤维的脑区不如BSE病例那样关键，在BSE病例中，纤维更容易从脑干区域提取。
