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Can metronidazole still be used for treatment of Clostridium difficile infections?

作者信息

Huang Haihui, Nord Carl Erik

机构信息

Department of Laboratory Medicine, F68, Karolinska University Hospital Huddinge, Karolinska Institute, SE-141 86, Stockholm, Sweden.

出版信息

Curr Infect Dis Rep. 2009 Jan;11(1):3-6. doi: 10.1007/s11908-009-0001-y.

DOI:10.1007/s11908-009-0001-y
PMID:19094818
Abstract
摘要

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本文引用的文献

1
Metronidazole is still the drug of choice for treatment of anaerobic infections.甲硝唑仍然是治疗厌氧菌感染的首选药物。
Clin Infect Dis. 2010 Jan 1;50 Suppl 1:S16-23. doi: 10.1086/647939.
2
Clostridium difficile--more difficult than ever.艰难梭菌——比以往任何时候都更难对付。
N Engl J Med. 2008 Oct 30;359(18):1932-40. doi: 10.1056/NEJMra0707500.
3
Emergence of reduced susceptibility to metronidazole in Clostridium difficile.艰难梭菌对甲硝唑敏感性降低的出现。
J Antimicrob Chemother. 2008 Nov;62(5):1046-52. doi: 10.1093/jac/dkn313. Epub 2008 Aug 7.
4
High levels of resistance to fluoroquinolones among Clostridium difficile isolates in a Spanish hospital.西班牙一家医院艰难梭菌分离株对氟喹诺酮类药物的高耐药水平。
Clin Infect Dis. 2008 Sep 15;47(6):818-22. doi: 10.1086/591201.
5
Metronidazole resistance in Clostridium difficile is heterogeneous.艰难梭菌对甲硝唑的耐药性具有异质性。
J Clin Microbiol. 2008 Sep;46(9):3028-32. doi: 10.1128/JCM.00524-08. Epub 2008 Jul 23.
6
Comparison of clinical and microbiological response to treatment of Clostridium difficile-associated disease with metronidazole and vancomycin.甲硝唑和万古霉素治疗艰难梭菌相关性疾病的临床及微生物学反应比较
Clin Infect Dis. 2008 Jul 1;47(1):56-62. doi: 10.1086/588293.
7
Both oral metronidazole and oral vancomycin promote persistent overgrowth of vancomycin-resistant enterococci during treatment of Clostridium difficile-associated disease.在艰难梭菌相关性疾病的治疗过程中，口服甲硝唑和口服万古霉素均会促使耐万古霉素肠球菌持续过度生长。
Antimicrob Agents Chemother. 2008 Jul;52(7):2403-6. doi: 10.1128/AAC.00090-08. Epub 2008 Apr 28.
8
Treatment of Clostridium difficile infection.艰难梭菌感染的治疗
Clin Infect Dis. 2008 Jan 15;46 Suppl 1:S32-42. doi: 10.1086/521860.
9
Outcome of metronidazole therapy for Clostridium difficile disease and correlation with a scoring system.甲硝唑治疗艰难梭菌病的结果及其与评分系统的相关性
J Infect. 2007 Dec;55(6):495-501. doi: 10.1016/j.jinf.2007.09.015. Epub 2007 Nov 5.
10
Outcomes of Clostridium difficile-associated disease treated with metronidazole or vancomycin before and after the emergence of NAP1/027.艰难梭菌相关性疾病在NAP1/027出现前后使用甲硝唑或万古霉素治疗的结果
Am J Gastroenterol. 2007 Dec;102(12):2781-8. doi: 10.1111/j.1572-0241.2007.01539.x. Epub 2007 Sep 26.