Leibovitz Eugene
Pediatric Infectious Disease Unit, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Vaccine. 2008 Dec 23;26 Suppl 7:G16-9. doi: 10.1016/j.vaccine.2008.11.008.
Complicated otitis media (OM) is a common paediatric problem and includes two major entities: persistent acute OM (AOM) and recurrent AOM (R-AOM). Double-tympanocentesis studies comparing the microbiology of initial and recurrent episodes of AOM have demonstrated that most recurrent episodes occurring within 1 month after antibiotic therapy are new infections, not true bacteriological relapses. These findings have highlighted the importance of bacteriological eradication in the prevention of subsequent R-AOM episodes. The seven-valent pneumococcal conjugate vaccine (PCV7) targets Streptococcus pneumoniae, one of the main AOM pathogens, and data on the impact of PCV7 on complications of AOM, such as mastoiditis, are presented.
复杂性中耳炎（OM）是一种常见的儿科疾病，包括两个主要类型：持续性急性中耳炎（AOM）和复发性急性中耳炎（R-AOM）。通过双鼓膜穿刺术研究比较AOM初始发作和复发发作的微生物学情况，结果表明，大多数在抗生素治疗后1个月内发生的复发发作是新感染，而非真正的细菌学复发。这些发现凸显了细菌学根除在预防后续R-AOM发作中的重要性。七价肺炎球菌结合疫苗（PCV7）针对主要的AOM病原体之一肺炎链球菌，并展示了PCV7对AOM并发症（如乳突炎）影响的数据。
