Yu Hongbo, Shahsafaei Aliakbar, Dorfman David M
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Am J Clin Pathol. 2009 Jan;131(1):33-41. doi: 10.1309/AJCP62WRKERPXDRT.
Gene expression profiling identified genes uniquely expressed by human germinal-center T-helper (GCTh) cells, including programmed death-1 (PD-1) and CXCL13. Recently, we demonstrated that PD-1 is an immunophenotypic marker of GCTh cells and angioimmunoblastic T-cell lymphoma (AITL). The goal of this study was to investigate the expression pattern of CXCL13 in comparison with PD-1. We studied 63 cases of T-cell lymphoproliferative disorders, including 22 cases of AITL. In cases of AITL, PD-1+ and CXCL13+ neoplastic cells were seen at foci of expanded CD21+ follicular dendritic cell networks. CXCL13 expression was limited in other peripheral T-cell lymphomas. PD-1 and CXCL13 identified germinal-center T-helper cells, showed a similar pattern of expression in AITL, and should serve as useful new markers for AITL. The similar pattern of expression of CXCL13 and PD-1 in AITL provides further evidence that AITL is a neoplasm derived from germinal-center T-helper cells.
基因表达谱分析鉴定出了人类生发中心辅助性T细胞（GCTh）独特表达的基因，包括程序性死亡受体1（PD-1）和CXC趋化因子配体13（CXCL13）。最近，我们证明PD-1是GCTh细胞和血管免疫母细胞性T细胞淋巴瘤（AITL）的免疫表型标志物。本研究的目的是比较CXCL13与PD-1的表达模式。我们研究了63例T细胞增殖性疾病，其中包括22例AITL。在AITL病例中，在扩大的CD21+滤泡树突状细胞网络区域可见PD-1+和CXCL13+肿瘤细胞。CXCL13在其他外周T细胞淋巴瘤中的表达有限。PD-1和CXCL13可识别生发中心辅助性T细胞，在AITL中显示出相似的表达模式，应作为AITL有用的新标志物。CXCL13和PD-1在AITL中相似的表达模式进一步证明AITL是一种源自生发中心辅助性T细胞的肿瘤。
