哌甲酯对一名成年阿斯伯格综合征合并注意力缺陷多动障碍患者的有效治疗：一项功能磁共振成像的临床研究
Effective methylphenidate treatment of an adult Aspergers Syndrome and a comorbid ADHD: a clinical investigation with fMRI.
作者信息
Roy Mandy, Dillo Wolfgang, Bessling Svenja, Emrich Hinderk M, Ohlmeier Martin D
机构信息
Hannover Medical School (MHH), Department of Psychiatry, Hannover, Germany.
出版信息
J Atten Disord. 2009 Jan;12(4):381-5. doi: 10.1177/1087054708320436.
OBJECTIVE
Aspergers Syndrome can present as comorbid with attention-deficit/hyperactivity disorder (ADHD). Very few cases of the assessment and treatment of this comorbidity in adulthood are described in the research literature.
METHOD
A 26-year-old patient as suffering from ADHD in combination with Aspergers Syndrome is diagnosed. Treatment is started with methylphenidate (MPH), and the patient's clinical response is observed, psychological tests concerning attention are analyzed, and a functional magnetic resonance imaging (fMRI) examination is performed during an attention-task.
RESULTS
On the functional magnetic resonance imaging, a reduction of cerebral activity bilaterally in the parietal lobe under the influence of MPH is detected.
CONCLUSION
Besides the neurophysiological findings, this case reports the complex impairment caused by the combination of AD/HD with Aspergers Syndrome and the broad social and behavioral benefits of treatment with MPH for this comorbidity.
目的
阿斯伯格综合征可能与注意力缺陷多动障碍（ADHD）共病。研究文献中很少描述成年期这种共病的评估和治疗案例。
方法
诊断出一名患有ADHD合并阿斯伯格综合征的26岁患者。开始使用哌甲酯（MPH）进行治疗，观察患者的临床反应，分析有关注意力的心理测试，并在注意力任务期间进行功能磁共振成像（fMRI）检查。
结果
在功能磁共振成像上，检测到在MPH的影响下双侧顶叶的大脑活动减少。
结论
除了神经生理学发现外，本病例报告了AD/HD与阿斯伯格综合征合并导致的复杂损害以及MPH治疗这种共病带来的广泛社会和行为益处。
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