Debess Jeanne, Riis Jens Østergaard, Pedersen Lars, Ewertz Marianne
Department of Oncology, Aalborg Hospital, Aarhus University, Denmark.
Acta Oncol. 2009;48(4):532-40. doi: 10.1080/02841860802600755.
The aim of this study was to assess cognitive function, quality of life, and psychological distress after surgery for early breast cancer but before initiation of adjuvant treatment.
We performed a population-based study in the county of North Jutland, Denmark, including 124 women aged less than 60 years who had surgery for early breast cancer from 2004 - 2006. They were compared with an aged-matched group of 224 women without previous cancer selected randomly from the same population. The cognitive function of patients and controls was tested using a revised battery from the ISPOCD study. Data were collected on quality of life (EORTC QLQ-C30) and psychological distress (POMS).
The neuropsychological tests did not reveal significant differences between patients and controls. Compared to the control group, breast cancer patients had a significantly 3 - 4 fold increased risk of experiencing cognitive impairment. Quality of life and psychological distress were also significantly poorer among patients.
This study demonstrated that women diagnosed with breast cancer experience a significant deterioration of their perceived cognitive functioning, quality of life and of psychological well being.
本研究旨在评估早期乳腺癌患者在手术治疗后但在辅助治疗开始前的认知功能、生活质量和心理困扰情况。
我们在丹麦北日德兰郡开展了一项基于人群的研究，纳入了124名年龄小于60岁、在2004年至2006年期间接受早期乳腺癌手术的女性。将她们与从同一人群中随机选取的224名无癌症病史的年龄匹配女性组成的对照组进行比较。使用ISPOCD研究修订版测试组对患者和对照组的认知功能进行测试。收集生活质量（欧洲癌症研究与治疗组织核心问卷QLQ-C30）和心理困扰（情绪状态量表POMS）的数据。
神经心理学测试未显示患者与对照组之间存在显著差异。与对照组相比，乳腺癌患者出现认知障碍的风险显著增加了3至4倍。患者的生活质量和心理困扰也明显更差。
本研究表明，被诊断为乳腺癌的女性在认知功能、生活质量和心理健康方面有显著恶化。
