Mahajan Bhawna, Vijayan Vannan Kandi, Agarwal Mahendra Kumar, Bansal Surendra Kumar
Department of Biochemistry, V. P. Chest Institute, University of Delhi, Delhi, India.
Biomarkers. 2008 Nov;13(7):713-27. doi: 10.1080/13547500802655367.
Asthma and chronic obstructive pulmonary disease (COPD) are diseases of airway inflammation with clinical and physiological similarities, making their differentiation difficult. Airway inflammatory changes are associated with systemic changes. However, no serum marker is known for their differentiation. Therefore, serum interleukin (IL)-1beta levels were determined. Out of a total of 1023 patients screened, we included in the study ten patients each with atopic asthma, non-atopic asthma and COPD and ten healthy subjects. Skin prick tests with 14 inhalant allergens were performed on each patient. Blood was collected in the symptomatic and asymptomatic phases of the diseases and serum IL-1beta and IgE levels were determined. Our results showed that in the symptomatic phase in asthmatics, serum IL-1beta levels were higher (P<0.05) than in patients with COPD. Serum IgE levels were higher (P<0.05) in atopic asthmatics than in non-atopic asthmatics and in COPD patients. We conclude that serum IL-1beta level determination during the symptomatic phase of the diseases may help to differentiate asthmatics from patients with COPD. Serum IgE levels may differentiate atopic asthmatics from non-atopic asthmatics and COPD patients.
哮喘和慢性阻塞性肺疾病（COPD）是气道炎症性疾病，在临床和生理方面存在相似之处，难以进行区分。气道炎症变化与全身变化相关。然而，尚无用于区分它们的血清标志物。因此，测定了血清白细胞介素（IL）-1β水平。在总共筛查的1023例患者中，我们纳入了研究，其中包括10例特应性哮喘患者、10例非特应性哮喘患者、10例COPD患者以及10名健康受试者。对每位患者进行了14种吸入性过敏原的皮肤点刺试验。在疾病的症状期和无症状期采集血液，测定血清IL-1β和IgE水平。我们的结果显示，在哮喘患者的症状期，血清IL-1β水平高于COPD患者（P<0.05）。特应性哮喘患者的血清IgE水平高于非特应性哮喘患者和COPD患者（P<0.05）。我们得出结论，在疾病的症状期测定血清IL-1β水平可能有助于区分哮喘患者和COPD患者。血清IgE水平可能有助于区分特应性哮喘患者与非特应性哮喘患者以及COPD患者。
