Cabarkapa Velibor, Stosić Zoran, Uzurov Vera, Sakac Vladimir, Derić Mirjana
Klinicki centar Vojvodine, Novi Sad Institut za laboratorijsku medicinu.
Med Pregl. 2008 Jul-Aug;61(7-8):389-92. doi: 10.2298/mpns0808389c.
Holotranscobalamin contains biologically available cobalamin because only holotranscobalamin promotes the uptake of the cobalamin therein by all cells, via specific receptors. Therefore holotranscobalamin has been proposed as a potentially useful alternative indicator of vitamin B12 status. The aim of the present study was to assess usefulness of holotranscobalamin in the evaluation of vitamin B12 status.
We examined serum level of holotranscobalamin in 135 subjects divided in four groups according to the serum concentration of vitamin B12: 30 subjects with vitamin B12 <154 pmol/l, 50 subjects with vitamin B12 154-250, 30 subjects with vitamin B12 2251-350 pmol/l, 25 subjects with vitamin B12 >350 pmol/l.
The results show that in subjects with low vitamin B12 serum level there are those with normal holotranscobalamin concentration (60%) and that in subjects with normal vitamin B12 there are those with low holotranscobalamin concentration (22%). The obtained results also show positive significant correlation between levels of holotranscobalamin and vitamin B12 (r = 0.62, p < -0.001).
We can conclude that biologically active cobalamin, holotranscobalamin, is a useful tool when examining vitamin B12 status especially in subjects with borderline and low vitamin B12 concentrations. Measurements of the serum holotranscobalamin may be superior to total serum cobalamin.
全转钴胺素含有生物可利用的钴胺素，因为只有全转钴胺素能通过特定受体促进所有细胞摄取其中的钴胺素。因此，全转钴胺素被提议作为维生素B12状态的一个潜在有用的替代指标。本研究的目的是评估全转钴胺素在评估维生素B12状态方面的有用性。
我们检测了135名受试者的血清全转钴胺素水平，这些受试者根据血清维生素B12浓度分为四组：30名维生素B12<154 pmol/l的受试者，50名维生素B12为154 - 250的受试者，30名维生素B12为251 - 350 pmol/l的受试者，25名维生素B12>350 pmol/l的受试者。
结果显示，维生素B12血清水平低的受试者中，有部分人的全转钴胺素浓度正常（60%）；而维生素B12正常的受试者中，有部分人的全转钴胺素浓度低（22%）。所得结果还显示全转钴胺素水平与维生素B12水平之间存在显著正相关（r = 0.62，p < -0.001）。
我们可以得出结论，具有生物活性的钴胺素，即全转钴胺素，在检测维生素B12状态时是一种有用的工具，尤其是在维生素B12浓度处于临界值和较低水平的受试者中。血清全转钴胺素的测量可能优于血清总钴胺素。
