发现噻吩类 Polo 样激酶抑制剂。
Discovery of thiophene inhibitors of polo-like kinase.
机构信息
Oncology R & D, GlaxoSmithKline, Five Moore Drive, PO Box 13398, Research Triangle Park, NC 27709, USA.
出版信息
Bioorg Med Chem Lett. 2009 Feb 1;19(3):1018-21. doi: 10.1016/j.bmcl.2008.11.041. Epub 2008 Nov 18.
PMID:19097784
Abstract
The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.
摘要
本文描述了一系列噻吩类化合物作为有效且选择性的 PLK 抑制剂的发现和开发。同时还介绍了 2 的鉴定和表征，它是一种有用的体外 PLK 抑制剂工具化合物。
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