Robson-Ansley Paula, Barwood Martin, Canavan Jane, Hack Susan, Eglin Clare, Davey Sarah, Hewitt Jennifer, Hull James, Ansley Les
School of Psychology and Sport Sciences, Northumbria University, Northumberland Road, Newcastle NE1 8ST, UK.
Cytokine. 2009 Feb;45(2):111-6. doi: 10.1016/j.cyto.2008.11.006. Epub 2008 Dec 18.
Strenuous, prolonged exercise increases interleukin-6 (IL-6) release. The effect of IL-6 is dependent on the availability of IL-6 receptors. Few studies have addressed the impact of exercise on IL-6 receptor levels or procalcitonin (PCT), an indicator of systemic inflammation. Changes in these molecules may give insight into cytokine-related mechanisms underlying exercise-related fatigue. Thirteen trained male subjects partook in the study. They cycled a total distance of 468 km over 6 days. Blood samples were obtained prior to and immediately following Day 1 of the study and then each morning prior to exercise. Blood samples were analysed for plasma IL-6, soluble IL-6 receptor (sIL-6R), C-reactive protein (CRP), PCT, creatine kinase (CK) and cortisol concentrations. Subjects also completed mood state questionnaires each day prior to exercise. IL-6 was elevated immediately post-exercise on Day 1 but was unchanged at rest for the duration of the event. In contrast, sIL-6R, CRP, PCT and CK concentrations were unchanged immediately post-exercise on Day 1 but were significantly elevated at rest over the duration of the event compared with pre-event baseline. sIL-6R was highly correlated to CRP. Cortisol concentrations remained unchanged at all time points. In conclusion, strenuous, prolonged exercise stimulated an acute phase response which was maintained throughout the 6-day event. sIL-6R increase is associated with CRP and may affect subjective sensations of post-exercise fatigue at rest.
剧烈、长时间运动可增加白细胞介素-6（IL-6）的释放。IL-6的作用取决于IL-6受体的可用性。很少有研究探讨运动对IL-6受体水平或降钙素原（PCT，全身炎症的一个指标）的影响。这些分子的变化可能有助于深入了解运动相关疲劳背后的细胞因子相关机制。13名受过训练的男性受试者参与了该研究。他们在6天内总共骑行468公里。在研究第1天之前和之后立即采集血样，然后在每天运动前的早晨采集血样。分析血样中的血浆IL-6、可溶性IL-6受体（sIL-6R）、C反应蛋白（CRP）、PCT、肌酸激酶（CK）和皮质醇浓度。受试者还在每天运动前完成情绪状态问卷。IL-6在第1天运动后立即升高，但在整个运动期间休息时保持不变。相比之下，sIL-6R、CRP、PCT和CK浓度在第1天运动后立即没有变化，但与运动前基线相比，在整个运动期间休息时显著升高。sIL-6R与CRP高度相关。皮质醇浓度在所有时间点均保持不变。总之，剧烈、长时间运动刺激了急性期反应，该反应在整个6天的运动期间持续存在。sIL-6R的增加与CRP相关，可能会影响休息时运动后疲劳的主观感受。
