Chan Paul K S, Luk Alfred C S, Luk Tommy N M, Lee Kwong-Fai, Cheung Jo L K, Ho King-Man, Lo Kuen-Kong
Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China.
J Clin Virol. 2009 Feb;44(2):111-4. doi: 10.1016/j.jcv.2008.11.001. Epub 2008 Dec 18.
A wide spectrum of human papillomavirus (HPV) types can infect the male genitalia. An HPV vaccine covering HPV6 and 11 is now available. Detailed data on the distribution of these two types in anogenital warts is needed to assess the potential benefits of the vaccine.
Anogenital wart specimens collected from 130 Chinese men were examined for HPV-type distribution by a method that covers a broad spectrum of high- and low-risk HPVs, and able to reveal multiple types from a single specimen.
Forty-four (33.8%) of the 130 specimens had a coinfection with multiple HPV types. In 63.1% of cases, only HPV6 and/or HPV11 were/was found. In 26.2% of cases, HPV6 and/or HPV11 were/was found together with one or more other HPV types. In 10.8% of specimens, only non-6/11 HPV types were found. HPV16 and/or 18 were/was found in 12 (9.2%) specimens, with majority (8/12, 66.7%) of which existed as coinfections with HPV6/11. Other HPV types found included HPV39, 51, 52, 55, 59, 61, 62, 68, 58, 72, 81, 83, 84 and CP6108.
A substantial proportion of HPV6/11-positive male anogenital warts are coinfected with other HPV types. The efficacy of HPV6/11 vaccine for preventing these lesions needs to be defined before the benefits of vaccinating men can be precisely assessed.
多种人乳头瘤病毒（HPV）类型可感染男性生殖器。目前已有涵盖HPV6和11型的HPV疫苗。需要有关这两种类型在肛门生殖器疣中分布的详细数据，以评估该疫苗的潜在益处。
采用一种涵盖广泛高风险和低风险HPV的方法，对从130名中国男性收集的肛门生殖器疣标本进行HPV类型分布检测，该方法能够从单个标本中检测出多种类型。
130个标本中有44个（33.8%）存在多种HPV类型的混合感染。在63.1%的病例中，仅发现HPV6和/或HPV11。在26.2%的病例中，HPV6和/或HPV11与一种或多种其他HPV类型同时被发现。在10.8%的标本中，仅发现非6/11型HPV。在12个（9.2%）标本中发现了HPV16和/或18，其中大多数（8/12，66.7%）与HPV6/11同时存在混合感染。发现的其他HPV类型包括HPV39、51、52、55、59、61、62、68、58、72、81、83、84和CP6108。
相当一部分HPV6/11阳性的男性肛门生殖器疣与其他HPV类型存在混合感染。在能够精确评估男性接种疫苗的益处之前，需要确定HPV6/11疫苗预防这些病变的疗效。
