Chitayat Lironn, Jovanovic Lois, Hod Moshe
Sansum Diabetes Research Institute, Santa Barbara, CA 93105, USA.
Semin Fetal Neonatal Med. 2009 Apr;14(2):72-6. doi: 10.1016/j.siny.2008.09.001. Epub 2008 Dec 18.
The development of drugs and devices in the treatment of pregnancies complicated by diabetes is in constant forward progression to compensate for pancreatic beta cell insufficiency. Maternal hyperglycemia during pregnancy is of particular interest due to the severe consequences that surface when a fetus is in development. The drugs that are currently recommended for use during pregnancy include rapid-acting insulin analogs lispro and aspart for meal-related bolus insulin and intermediate-acting NPH for basal insulin. Oral anti-diabetic agents are not recommended for use during pregnancy. Better control may be achieved with the incorporation of real-time glucose sensors and new insulin pumps with hopes of improving pregnancy outcome.
用于治疗合并糖尿病妊娠的药物和设备不断向前发展，以弥补胰腺β细胞功能不全。孕期母体高血糖尤其值得关注，因为胎儿发育时会出现严重后果。目前推荐在孕期使用的药物包括用于餐时大剂量胰岛素的速效胰岛素类似物赖脯胰岛素和门冬胰岛素，以及用于基础胰岛素的中效中性鱼精蛋白锌胰岛素。不建议在孕期使用口服抗糖尿病药物。结合实时葡萄糖传感器和新型胰岛素泵有望更好地控制血糖，改善妊娠结局。
