氨基酸输注后分离的大鼠肝脏中血管球加压素的产生

Glomerulopressin production by isolated rat liver after amino acid infusion.

作者信息

Silberstein C, Brandariz S, Arteman P, Aguirre J, Uranga J, del Castillo E

机构信息

Instituto de Biologia y Medicina Experimental, Buenos Aires, Argentina.

出版信息

Proc Soc Exp Biol Med. 1991 Oct;198(1):625-8. doi: 10.3181/00379727-198-43299.

DOI:10.3181/00379727-198-43299

PMID:1909796

Abstract

The infusion of certain amino acids, such as serine, alanine, and proline (SAP), has been shown to increase the glomerular filtration rate, whereas branched chain amino acids (BCAA) leucine, isoleucine, and valine fail to modify the glomerular filtration rate. It has been suggested that this effect of amino acids on the glomerular filtration rate is mediated by the action of the hormone glomerulopressin. The purpose of this work was to study the action of SAP and BCAA on glomerulopressin production. Livers isolated from rats were perfused with (i) Krebs-Ringer-Bicarbonate, (ii) SAP, or (iii) BCAA. Results indicate that glomerulopressin production is stimulated by SAP, but inhibited by BCAA.

摘要

输注某些氨基酸，如丝氨酸、丙氨酸和脯氨酸（SAP），已被证明可提高肾小球滤过率，而支链氨基酸（BCAA）亮氨酸、异亮氨酸和缬氨酸则无法改变肾小球滤过率。有人认为，氨基酸对肾小球滤过率的这种作用是由激素肾小球加压素的作用介导的。这项工作的目的是研究SAP和BCAA对肾小球加压素产生的作用。从大鼠分离的肝脏用（i） Krebs-Ringer-碳酸氢盐、（ii） SAP或（iii） BCAA进行灌注。结果表明，SAP刺激肾小球加压素的产生，但BCAA抑制其产生。