4-羟基-2-环戊烯酮：一种来自四籽西番莲的抗假单胞菌和细胞毒性成分。

4-Hydroxy-2-cyclopentenone: an anti-Pseudomonas and cytotoxic component from Passiflora tetrandra.

作者信息

Perry N B, Albertson G D, Blunt J W, Cole A L, Munro M H, Walker J R

机构信息

Department of Chemistry, University of Canterbury, Christchurch, New Zealand.

出版信息

Planta Med. 1991 Apr;57(2):129-31. doi: 10.1055/s-2006-960048.

DOI:10.1055/s-2006-960048

PMID:1909798

Abstract

4-Hydroxy-2-cyclopentenone is responsible for the anti-bacterial activity of an extract of leaves from Passiflora tetrandra with minimum inhibitory doses (MID) of ca. 10 micrograms/disk against Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa. 4-Hydroxy-2-cyclopentenone is also cytotoxic to P388 murine leukemia cells (IC50 of less than 1 microgram/ml).

摘要

4-羟基-2-环戊烯酮是西番莲叶提取物抗菌活性的原因，其对大肠杆菌、枯草芽孢杆菌和铜绿假单胞菌的最小抑菌剂量（MID）约为10微克/圆盘。4-羟基-2-环戊烯酮对P388小鼠白血病细胞也具有细胞毒性（IC50小于1微克/毫升）。