Zhong Yun, Wu Susan, Andaz Shahriyour, Danovich Svetlana, Lin Jen
Department of Pathology, South Nassau Communities Hospital, One Healthy Way, Oceanside, New York, USA.
Int J Surg Pathol. 2011 Feb;19(1):71-4. doi: 10.1177/1066896908329594. Epub 2008 Dec 18.
A rare case of pulmonary carcinoid tumor exhibiting morphologically as a monophasic synovial sarcoma is reported. The patient is a 37-year-old man who presented with shortness of breath for several weeks. The chest computed tomographic scan showed a 3.5 cm pulmonary mass in the left lower lobe.The lesion was an oval, tan nodule displaying features of monophasic synovial sarcoma. Immunohistochemical studies were performed and included a carcinoid tumor as a main differential diagnosis. Reverse transcriptase polymerase chain reaction and fluorescence in situ hybridization studies were negative for a molecular evidence of synovial sarcoma. This case further emphasizes the capacity of pulmonary carcinoid tumor cells to show various morphologic expressions even toward a mesenchymal differentiation mimicking a synovial sarcoma.
报告了一例形态学表现为单相滑膜肉瘤的罕见肺类癌肿瘤病例。患者为一名37岁男性，因气短数周就诊。胸部计算机断层扫描显示左肺下叶有一个3.5 cm的肺部肿块。病变为椭圆形、棕褐色结节，具有单相滑膜肉瘤的特征。进行了免疫组织化学研究，将类癌肿瘤作为主要鉴别诊断。逆转录酶聚合酶链反应和荧光原位杂交研究未发现滑膜肉瘤的分子证据。该病例进一步强调了肺类癌肿瘤细胞即使向模仿滑膜肉瘤的间充质分化也能表现出各种形态学表达的能力。
