Morgan W H, Hazelton M L, Balaratnasingamm C, Chan H, House P H, Barry C J, Cringle S J, Yu D-Y
Department of Physiology and Pharmacology, Lions Eye Institute, Nedlands, Western Australia, Australia.
Br J Ophthalmol. 2009 May;93(5):594-6. doi: 10.1136/bjo.2008.149963. Epub 2008 Dec 19.
Retinal vein ophthalmodynamometric force (ODF) is predictive of future optic disc excavation in glaucoma, but it is not known if variation in ODF affects prognosis. We aimed to assess whether a change in ODF provides additional prognostic information.
135 eyes of 75 patients with glaucoma or being glaucoma suspects had intraocular pressure (IOP), visual fields, stereo optic disc photography and ODF measured on an initial visit and a subsequent visit at mean 82 (SD 7.3) months later. Corneal thickness and blood pressure were recorded on the latter visit. When venous pulsation was spontaneous, the ODF was recorded as 0 g. Change in ODF was calculated. Flicker stereochronoscopy was used to determine the occurrence of optic disc excavation, which was modelled against the measured variables using multiple mixed effects logistic regression.
Change in ODF (p = 0.046) was associated with increased excavation. Average IOP (p = 0.66) and other variables were not associated. Odds ratio for increased optic disc excavation of 1.045 per gram ODF change (95% CI 1.001 to 1.090) was calculated.
Change in retinal vein ODF may provide additional information to assist with glaucoma prognostication and implies a significant relationship between venous change and glaucoma patho-physiology.
视网膜静脉眼动力测量力（ODF）可预测青光眼患者未来的视盘凹陷情况，但ODF的变化是否影响预后尚不清楚。我们旨在评估ODF的变化是否能提供额外的预后信息。
75例青光眼患者或青光眼疑似患者的135只眼睛在初次就诊时测量了眼压（IOP）、视野、立体视盘摄影和ODF，并在平均82（标准差7.3）个月后的后续就诊时再次测量。在后续就诊时记录角膜厚度和血压。当静脉搏动为自发性时，ODF记录为0克。计算ODF的变化。使用闪烁立体同步镜检查来确定视盘凹陷的发生情况，并使用多重混合效应逻辑回归对测量变量进行建模。
ODF的变化（p = 0.046）与凹陷增加相关。平均眼压（p = 0.66）和其他变量无关。计算出每克ODF变化导致视盘凹陷增加的优势比为1.045（95%可信区间1.001至1.090）。
视网膜静脉ODF的变化可能提供额外信息以辅助青光眼的预后评估，并暗示静脉变化与青光眼病理生理学之间存在显著关系。
