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[实验性甲状腺功能减退症时肝脏的超微结构变化]

[Ultrastructural changes in the liver in experimental hypothyroidism].

作者信息

Galakhin K A, Sharov V G

出版信息

Arkh Patol. 1977 Jan;39(1):47-52.

PMID:190983
Abstract

Electron microscopic studies of the liver of thyroidectomized rabbits were carried out. Ultrastructural changes in hepatocytes at various periods after the operation were established. Morphological changes in hepatic cells occurred already at early stages of hypothyrosis (1 month) and led to considerable dystrophyc processes at later stages of the experiment. In the hepatic tissue there was noted a marked myxedema, as well as a considerable intracellular edema which led to destruction of hepatocytes. The studies conducted revealed lesion of the morphological structure of the liver, impairment of general metabolic processes and of the hepatic function.

摘要

对甲状腺切除的兔子肝脏进行了电子显微镜研究。确定了术后不同时期肝细胞的超微结构变化。肝细胞的形态学变化在甲状腺功能减退的早期(1个月)就已出现,并在实验后期导致相当严重的营养不良过程。在肝组织中观察到明显的黏液性水肿,以及相当严重的细胞内水肿,这导致肝细胞破坏。所进行的研究揭示了肝脏形态结构的损伤、一般代谢过程和肝功能的损害。

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