Horsager Alan, Greenwald Scott H, Weiland James D, Humayun Mark S, Greenberg Robert J, McMahon Matthew J, Boynton Geoffrey M, Fine Ione
Neuroscience Graduate Program, University of Southern California, Los Angeles, California, USA.
Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1483-91. doi: 10.1167/iovs.08-2595. Epub 2008 Dec 20.
With the long-term goal of restoring functional vision in patients with retinal degenerative diseases, the eyes of blind human subjects were implanted chronically with epiretinal prostheses consisting of two-dimensional electrode arrays that directly stimulated cells of the neural retina.
Psychophysical techniques were used to measure the brightness of electrically generated percepts on single electrodes using a variety of electrical stimulation patterns.
It was possible to predict the sensitivity of the human visual system to a wide variety of retinal electrical stimulation patterns using a simple and biologically plausible model.
This is the first study to demonstrate that, on the single-electrode level, retinal electrical stimulation in humans can produce visual qualia that are predictable using a quantitative model, a prerequisite for a successful retinal prosthesis. (ClinicalTrials.gov number, NCT00279500.).
为了实现恢复视网膜退行性疾病患者功能性视力的长期目标，将由二维电极阵列组成的视网膜外假体长期植入盲人受试者眼中，该电极阵列可直接刺激神经视网膜细胞。
采用心理物理学技术，使用多种电刺激模式测量单个电极上电产生感知的亮度。
使用简单且符合生物学原理的模型，可以预测人类视觉系统对多种视网膜电刺激模式的敏感性。
这是第一项证明在单电极水平上，人类视网膜电刺激能够产生可通过定量模型预测的视觉感受质的研究，这是成功的视网膜假体的一个先决条件。（ClinicalTrials.gov编号，NCT00279500。）
