Department of Psychology, University of Washington, Seattle, 98195, USA.
Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Sci Rep. 2024 Jul 29;14(1):17400. doi: 10.1038/s41598-024-65337-1.
The field of cortical sight restoration prostheses is making rapid progress with three clinical trials of visual cortical prostheses underway. However, as yet, we have only limited insight into the perceptual experiences produced by these implants. Here we describe a computational model or 'virtual patient', based on the neurophysiological architecture of V1, which successfully predicts the perceptual experience of participants across a wide range of previously published human cortical stimulation studies describing the location, size, brightness and spatiotemporal shape of electrically induced percepts in humans. Our simulations suggest that, in the foreseeable future the perceptual quality of cortical prosthetic devices is likely to be limited by the neurophysiological organization of visual cortex, rather than engineering constraints.
皮质视觉假体领域正在快速发展，目前正在进行三项视觉皮质假体临床试验。然而，到目前为止，我们对这些植入物产生的感知体验只有有限的了解。在这里，我们描述了一个基于 V1 神经生理学结构的计算模型或“虚拟患者”，该模型成功地预测了广泛的先前发表的人类皮质刺激研究中参与者的感知体验，这些研究描述了在人类中电诱导感知的位置、大小、亮度和时空形状。我们的模拟表明，在可预见的未来，皮质假体设备的感知质量可能受到视觉皮层的神经生理学组织的限制，而不是工程限制。
