Andisheh-Tadbir Azadeh, Mehrabani Davood, Heydari Seyed Taghi
Department of Oral Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
J Craniofac Surg. 2008 Nov;19(6):1699-702. doi: 10.1097/SCS.0b013e31818c04cc.
Squamous cell carcinoma accounts for approximately 90% of oral malignancies. This study was performed to determine the prevalence of oral squamous cell carcinoma (OSCC) in southern Iran in relation to sex, age, subsite distribution, and histologic differentiation of the tumor. Pathologic records of patients with a histologic diagnosis of OSCC at Fars Cancer Registry of Nemazee Hospital affiliated to Shiraz University of Medical Sciences during the period of April 1992 through March 2007 were reviewed. Among 11,220 cases of cancer registered during this period, 200 cases were OSCC (1.7%). The age range of patients was 4 to 87 years (mean, 56.9 years; SD, 15.5 years), with a 1.4:1 male-female ratio. Oral squamous cell carcinoma occurred more frequently in patients older than 60 years. The tongue was the most commonly affected site (53%), followed by the buccal mucosa (9.5%) and maxillary gingiva (9%). The well-differentiated type (55.5%) was the most common, with the poorly differentiated OSCC being the least common (7.5%). The present study showed that OSCC was the most common malignancy in the tongue and buccal mucosa being more common in older age and male sex.
鳞状细胞癌约占口腔恶性肿瘤的90%。本研究旨在确定伊朗南部口腔鳞状细胞癌（OSCC）在性别、年龄、发病部位分布以及肿瘤组织学分化方面的患病率。回顾了设拉子医科大学附属内马齐医院法尔斯癌症登记处1992年4月至2007年3月期间组织学诊断为OSCC患者的病理记录。在此期间登记的11220例癌症病例中，200例为OSCC（1.7%）。患者年龄范围为4至87岁（平均56.9岁；标准差15.5岁），男女比例为1.4:1。口腔鳞状细胞癌在60岁以上患者中更为常见。舌是最常受累部位（53%），其次是颊黏膜（9.5%）和上颌牙龈（9%）。高分化型（55.5%）最为常见，低分化OSCC最不常见（7.5%）。本研究表明，OSCC是舌部最常见的恶性肿瘤，颊黏膜OSCC在老年男性中更为常见。
