Picciocchi A, Magistrelli P, Coco C, Masetti R, Roncolini G, Perrotti P, Cellini N, Valentini V
Department of General Surgery (Semeiotica Chirurgica), Università Cattolica del Sacro Cuore, Rome, Italy.
J Surg Oncol Suppl. 1991;2:141-3. doi: 10.1002/jso.2930480530.
One hundred and twelve patients with locally advanced adenocarcinoma of the rectum have been treated with a protocol of adjuvant radiotherapy from 1981 to 1989. Radiotherapy was administered with a "sandwich" method at a dosage of 2700 cGy preoperatively and of 1800 cGy post-operatively. Only patients in stages B and C have been considered for results. Postoperative morbidity has been 16% and postoperative mortality 2.7%. Local failure was seen in 20% of patients without significant differences by stage, location, grading and operative technique. Distant metastases were seen in 31% of patients. Five-year actuarial survival was 49% and respectively 58% in stage B and 38% in stage C (P less than 0.01). Compared with a series of historical controls treated with surgery alone, the local recurrence rate was 20% vs. 26%, the distant metastases rate was 31% vs. 38% and the five-year actuarial survival rate was 49% vs. 36% (P greater than 0.01).
1981年至1989年期间，112例局部晚期直肠癌患者接受了辅助放疗方案。放疗采用“三明治”方法，术前剂量为2700 cGy，术后剂量为1800 cGy。仅对B期和C期患者的结果进行了分析。术后发病率为16%，术后死亡率为2.7%。20%的患者出现局部复发，在分期、位置、分级和手术技术方面无显著差异。31%的患者出现远处转移。B期患者的5年精算生存率为58%，C期为38%（P<0.01）。与一系列仅接受手术治疗的历史对照相比，局部复发率分别为20%和26%，远处转移率分别为31%和38%，5年精算生存率分别为49%和36%（P>0.01）。
