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苯妥英钠所致可逆性亚急性周围神经病

Reversible subacute peripheral neuropathy induced by phenytoin.

作者信息

Dobkin B H

出版信息

Arch Neurol. 1977 Mar;34(3):189-90. doi: 10.1001/archneur.1977.00500150075015.

DOI:10.1001/archneur.1977.00500150075015
PMID:190987
Abstract

Dysesthesia and sensory and reflex loss in the legs developed in a patient treated for seizures with phenytoin (diphenylhydantoin) for one year. Her serum drug levels had been in the therapeutic range, and no other clinical toxic reactions had been noted. The peripheral neuropathy resolved when phenytoin therapy was discontinued.

摘要

一名使用苯妥英钠(二苯乙内酰脲)治疗癫痫一年的患者出现腿部感觉异常以及感觉和反射丧失。她的血清药物水平一直处于治疗范围内,且未观察到其他临床毒性反应。停用苯妥英钠治疗后,周围神经病变得到缓解。

相似文献

1
Reversible subacute peripheral neuropathy induced by phenytoin.苯妥英钠所致可逆性亚急性周围神经病
Arch Neurol. 1977 Mar;34(3):189-90. doi: 10.1001/archneur.1977.00500150075015.
2
Clinical and electrophysiologic evaluation of peripheral nerve function in chronic phenytoin therapy.
Epilepsia. 1985 Sep-Oct;26(5):416-20. doi: 10.1111/j.1528-1157.1985.tb05672.x.
3
Peripheral neuropathy in long-term diphenylhydantoin therapy.长期苯妥英钠治疗所致的周围神经病变
Trans Am Neurol Assoc. 1967;92:262-4.
4
Motor nerve conduction study in patients on diphenylhydantoin therapy.接受苯妥英治疗患者的运动神经传导研究。
J Neurol Neurosurg Psychiatry. 1975 Dec;38(12):1235-9. doi: 10.1136/jnnp.38.12.1235.
5
Peripheral neuropathy in epileptic patients.
Neurology. 1981 Jul;31(7):826-31. doi: 10.1212/wnl.31.7.826.
6
Peripheral neuropathy in long-term diphenylhydantoin therapy.
Arch Neurol. 1968 Jan;18(1):69-77. doi: 10.1001/archneur.1968.00470310083007.
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Peripheral nerve function in long-term therapy with diphenylhydantoin. A clinical and electrophysiologic correlation.苯妥英长期治疗中的周围神经功能。临床与电生理相关性
Neurology. 1974 May;24(5):411-7. doi: 10.1212/wnl.24.5.411.
8
Peripheral neuropathy in children on long-term phenytoin therapy.
Brain Dev. 1981;3(4):375-83. doi: 10.1016/s0387-7604(81)80066-6.
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Extremely acute phenytoin-induced peripheral neuropathy.
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Side effects of antiepileptic drugs: a peripheral neuropathy due to diphenylhydantoin (DPH) intoxication.抗癫痫药物的副作用:由苯妥英(DPH)中毒引起的周围神经病变。
Folia Psychiatr Neurol Jpn. 1980;34(3):314-5. doi: 10.1111/j.1440-1819.1980.tb01549.x.

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