苯妥英钠所致可逆性亚急性周围神经病

Reversible subacute peripheral neuropathy induced by phenytoin.

作者信息

Dobkin B H

出版信息

Arch Neurol. 1977 Mar;34(3):189-90. doi: 10.1001/archneur.1977.00500150075015.

DOI:10.1001/archneur.1977.00500150075015

PMID:190987

Abstract

Dysesthesia and sensory and reflex loss in the legs developed in a patient treated for seizures with phenytoin (diphenylhydantoin) for one year. Her serum drug levels had been in the therapeutic range, and no other clinical toxic reactions had been noted. The peripheral neuropathy resolved when phenytoin therapy was discontinued.

摘要

一名使用苯妥英钠（二苯乙内酰脲）治疗癫痫一年的患者出现腿部感觉异常以及感觉和反射丧失。她的血清药物水平一直处于治疗范围内，且未观察到其他临床毒性反应。停用苯妥英钠治疗后，周围神经病变得到缓解。