Gasser Robin B, Cantacessi Cinzia, Campbell Bronwyn E
Department of Veterinary Science, The University of Melbourne, Werribee, Victoria 3030, Australia.
Expert Rev Mol Diagn. 2009 Jan;9(1):17-21. doi: 10.1586/14737159.9.1.17.
Blood-feeding hookworms are parasitic roundworms (i.e., nematodes) of major socioeconomic importance, affecting millions of people worldwide. Despite their impact on human health, little attention has been paid to improving practical methods of diagnosis. The genetic characterization of hookworms and specific diagnosis of their infections are central to elucidating the ecology and epidemiology of these parasites as well as the control of the disease they cause. Traditional coprodiagnostic methods have major limitations. This article summarizes progress in the development of molecular-analytical and -diagnostic tools, and discusses the need to establish practical 'laboratory' and 'field' assays for use in integrated hookworm prevention and control programs.
吸血钩虫是具有重大社会经济意义的寄生线虫（即蛔虫），影响着全球数百万人。尽管它们对人类健康有影响，但在改进实际诊断方法方面却很少受到关注。钩虫的基因特征及其感染的特异性诊断对于阐明这些寄生虫的生态学和流行病学以及控制它们所引起的疾病至关重要。传统的粪便诊断方法有很大局限性。本文总结了分子分析和诊断工具开发方面的进展，并讨论了建立实用的“实验室”和“现场”检测方法以用于钩虫综合防治计划的必要性。
