Konje J C, Otolorin E O, Ladipo O A
Department of Obstetrics and Gynaecology, University College Hospital, Ibadan, Nigeria.
Contraception. 1991 Aug;44(2):163-72. doi: 10.1016/0010-7824(91)90116-w.
During a 30-month period, changes in carbohydrate metabolism (measured by oral glucose tolerance test) were studied in 20 Norplant acceptors. Changes were first observed one month after Norplant insertion and peaked between 12-18 months. The area under the glucose curve rose by 12.3% and 40.5% one and 12 months post insertion, respectively. At 18, 24 and 30 months the rise was, respectively, 41.9%, 40% and 38.6%. Although the changes under the insulin curves were similar, the increase at one month was doubled (25.7%). Only fasting insulin values showed very slight and insignificant changes during the 30-month period. All the changes were, however, within the normal limits for healthy women. We conclude that although Norplant induces changes in carbohydrate metabolism, these changes remain within normal limits, peak at 12 months and either remain the same or decrease with time.
在30个月的时间里，对20名使用诺普兰皮下埋植剂的女性进行了碳水化合物代谢变化（通过口服葡萄糖耐量试验测量）的研究。变化在植入诺普兰皮下埋植剂后1个月首次观察到，并在12至18个月达到峰值。葡萄糖曲线下面积在植入后1个月和12个月分别上升了12.3%和40.5%。在18、24和30个月时，上升幅度分别为41.9%、40%和38.6%。尽管胰岛素曲线下的变化相似，但1个月时的增幅翻倍（25.7%）。在30个月期间，只有空腹胰岛素值显示出非常轻微且无统计学意义的变化。然而，所有变化都在健康女性的正常范围内。我们得出结论，尽管诺普兰皮下埋植剂会引起碳水化合物代谢变化，但这些变化仍在正常范围内，在12个月达到峰值，之后要么保持不变，要么随时间下降。
