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隐源性肝损伤、心力衰竭与高龄:一例病例报告

Cryptogenic hepatic insult, failing heart and advancing age: a case report.

作者信息

Agrawal Akansha, Soneja Manish, Goel Ashish, Pati H, Dey Aparajit B

机构信息

Department of Medicine, All India Institute of Medical Sciences, ND 110029, India.

出版信息

Cases J. 2008 Dec 19;1(1):408. doi: 10.1186/1757-1626-1-408.

DOI:10.1186/1757-1626-1-408
PMID:19099563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2640368/
Abstract

BACKGROUND

Weakness and fatigue are accepted as normal accompaniments of aging. Usually, older individuals are not investigated with much enthusiasm but a treatable cause is discernible on several occasions.

CASE PRESENTATION

We had a 67 year old hypertensive lady with a mitral stenosis, presenting in ischemic or hypertensive heart failure with underlying valvular disease, without pulmonary hypertension in sinus rhythm. She had pancytopenia with severe anemia and raised liver enzymes. Bone marrow examination showed aplastic anemia. She was treated with ATG and improved subsequently to become transfusion free. However, she succumbed to an unrelated sudden cardiac death.

CONCLUSION

Our patient is unique in her uncommon presentation, complex management issues and a favorable outcome after a long and persevering therapeutic intervention and finally her sudden death.

摘要

背景

虚弱和疲劳被认为是衰老的正常伴随症状。通常情况下,老年个体不会受到太多关注,但在某些情况下可发现可治疗的病因。

病例报告

我们有一位67岁的高血压女性,患有二尖瓣狭窄,表现为缺血性或高血压性心力衰竭,伴有潜在瓣膜疾病,窦性心律时无肺动脉高压。她全血细胞减少,伴有严重贫血和肝酶升高。骨髓检查显示再生障碍性贫血。她接受了抗胸腺细胞球蛋白治疗,随后病情改善,无需输血。然而,她死于一次无关的心脏猝死。

结论

我们的患者在其不寻常的表现、复杂的管理问题以及经过长期且坚持不懈的治疗干预后取得良好结果,最终突然死亡方面具有独特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa7/2640368/45e8546e2506/1757-1626-1-408-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa7/2640368/45e8546e2506/1757-1626-1-408-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa7/2640368/45e8546e2506/1757-1626-1-408-1.jpg

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本文引用的文献

1
Immunosuppressive therapy for acquired severe aplastic anemia (SAA): a prospective comparison of four different regimens.获得性重型再生障碍性贫血(SAA)的免疫抑制治疗:四种不同方案的前瞻性比较。
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[Successful combined therapy with ATG, cyclosporin and G-CSF for both liver dysfunction and bone marrow failure in hepatitis-associated aplastic anemia].[抗胸腺细胞球蛋白、环孢素和粒细胞集落刺激因子联合治疗肝炎相关性再生障碍性贫血合并肝功能不全和骨髓衰竭成功]
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Anemia in the elderly.
老年人贫血
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A patient with non-A, non-B, non-C hepatitis-associated aplastic anemia recovered promptly following immuno-suppressive therapy, including antithymocyte globulin.一名患有非甲、非乙、非丙型肝炎相关性再生障碍性贫血的患者在接受包括抗胸腺细胞球蛋白在内的免疫抑制治疗后迅速康复。
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