Ma Yang-Li, Hou Jian
Department of Hematology, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Dec;16(6):1459-64.
Multiple myeloma (MM) is characterized by a population of functionally heterogeneous cells, in which identifying the target cells causing molecular lesion is a fundamental issue. The resultant tumor stem/progenitor cells comprise only a minor portion of the myeloma cells, which give rise through differentiation to more committed progenitors as well as differentiated blasts that constitute the bulk of the tumor. Although they are rare as compared with fully differentiated plasma cells, MM stem/progenitor cells are likely responsible for the maintenance and progression of disease through the production of new tumor cells. Thus, this is the cell population which must be eradicated for successful treatment. This article reviewed apparently conflicting evidence pertaining to the cellular origins of MM and proposed that myeloma may originate in more cellular components. In this article, the nature of the target cells, the identification and phenotypic analyses of clonogenic myeloma cells, the signaling pathways within myeloma stem/progenitor cells and the target therapy related were reviewed as well.
多发性骨髓瘤（MM）的特征是一群功能异质性细胞，其中识别导致分子病变的靶细胞是一个基本问题。由此产生的肿瘤干/祖细胞仅占骨髓瘤细胞的一小部分，它们通过分化产生更多定向祖细胞以及构成肿瘤主体的分化母细胞。尽管与完全分化的浆细胞相比它们很罕见，但MM干/祖细胞可能通过产生新的肿瘤细胞而对疾病的维持和进展负责。因此，这是成功治疗必须根除的细胞群。本文综述了与MM细胞起源明显矛盾的证据，并提出骨髓瘤可能起源于更多细胞成分。本文还综述了靶细胞的性质、克隆性骨髓瘤细胞的鉴定和表型分析、骨髓瘤干/祖细胞内的信号通路以及相关的靶向治疗。
