一种新的脑特异性25 kDa蛋白（p25）被来自tau蛋白激酶组分的丝氨酸/苏氨酸-脯氨酸激酶（TPK II）磷酸化。
A novel brain-specific 25 kDa protein (p25) is phosphorylated by a Ser/Thr-Pro kinase (TPK II) from tau protein kinase fractions.
作者信息
Takahashi M, Tomizawa K, Ishiguro K, Sato K, Omori A, Sato S, Shiratsuchi A, Uchida T, Imahori K
机构信息
Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
出版信息
FEBS Lett. 1991 Sep 2;289(1):37-43. doi: 10.1016/0014-5793(91)80903-g.
A novel brain-specific 25 kDa protein (p25) was purified from a bovine brain extract. The protein was phosphorylated by Ser/Thr-Pro kinase (TPK II) in tau protein kinase fractions at the Ser residues of Ser-Pro sequences. Using immunoblot analysis, the protein was found only in brain extracts, and was most abundant in the brain regions such as cerebrum and hippocampus, but less abundant in cerebellum, medulla oblongata and olfactory bulb. The protein was detected in rat, bovine and human brain extracts, indicating that this protein specifically exists in mammalian brain tissues.
从牛脑提取物中纯化出一种新型的脑特异性25 kDa蛋白（p25）。该蛋白在tau蛋白激酶组分中被丝氨酸/苏氨酸-脯氨酸激酶（TPK II）在丝氨酸-脯氨酸序列的丝氨酸残基处磷酸化。通过免疫印迹分析发现，该蛋白仅存在于脑提取物中，在大脑和海马体等脑区中含量最高，而在小脑、延髓和嗅球中含量较少。在大鼠、牛和人类脑提取物中均检测到该蛋白，表明这种蛋白特异性存在于哺乳动物脑组织中。
Zotero 插件