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[关节置换相关感染:发病率、危险因素、临床特征及结局]

[Arthroplasty-related infection: incidence, risk factors, clinical features, and outcome].

作者信息

Rodríguez-Baño Jesús, del Toro María Dolores, Lupión Carmen, Suárez Ana Isabel, Silva Luis, Nieto Isabel, Muniain Miguel Angel

机构信息

Sección de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, Sevilla, Spain.

出版信息

Enferm Infecc Microbiol Clin. 2008 Dec;26(10):614-20. doi: 10.1016/s0213-005x(08)75277-7.

Abstract

INTRODUCTION

There is little information about the overall incidence, risk factors, and clinical management of arthroplasty-related infection in Spain.

METHODS

The incidence of surgical site infection (SSI) in hip and knee arthroplasty from 2001 to 2005 was determined. Risk factors for SSI were investigated in 435 patients using multivariate logistic regression analysis. Clinical features and treatment were examined in a cohort of 58 consecutive patients with joint arthroplasty infection.

RESULTS

The percentages of SSI in hip and knee arthroplasty stratified according to the National Nosocomial Infection Surveillance (NNIS) index were 1.86% and 1.62% (NNIS=0), 3.72% and 2.02% (NNIS=1), and 7.20% and 6.71% (NNIS=2-3), respectively. The risk factors identified for developing SSI included secondary arthroplasty, duration of urinary catheterization, and hip arthroplasty. Fifty percent of patients with arthroplasty infection had type I (early) or III (hematogenous) infection. Gram-positive cocci were the most frequent causes. Initial therapy consisted in debridement with preservation of the prosthesis (10 patients) or removal of the prosthesis (40 patients); surgery was not performed in 8 patients. After one year of follow up, 39 patients (67%) were considered cured, 12 (21%) had a recurrence or were under chronic suppressive antimicrobial therapy, and 7 (12%) had died.

CONCLUSIONS

The incidence of SSI in our center is similar to that of other Spanish hospitals, but is higher than the notified incidence in the NNIS system. A modifiable risk factor (urinary catheterization) has been identified. Greater consensus for the management of these patients is desirable.

摘要

引言

关于西班牙人工关节置换术相关感染的总体发病率、危险因素及临床管理的信息较少。

方法

确定2001年至2005年髋膝关节置换术中手术部位感染(SSI)的发病率。采用多因素逻辑回归分析对435例患者的SSI危险因素进行调查。对58例连续性关节置换术感染患者的临床特征及治疗情况进行研究。

结果

根据国家医院感染监测(NNIS)指数分层,髋膝关节置换术中SSI的发生率分别为:NNIS=0时为1.86%和1.62%,NNIS=1时为3.72%和2.02%,NNIS=2 - 3时为7.20%和6.71%。确定的发生SSI的危险因素包括二次关节置换术、导尿持续时间及髋关节置换术。50%的关节置换术感染患者为I型(早期)或III型(血源性)感染。革兰氏阳性球菌是最常见的病因。初始治疗包括保留假体的清创术(10例患者)或假体取出术(40例患者);8例患者未进行手术。随访一年后,39例患者(67%)被认为治愈,12例(21%)复发或接受慢性抑制性抗菌治疗,7例(12%)死亡。

结论

我们中心SSI的发生率与其他西班牙医院相似,但高于NNIS系统报告的发生率。已确定一个可改变的危险因素(导尿)。对于这些患者的管理需要达成更大的共识。

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