del Toro M D, Nieto I, Guerrero F, Corzo J, del Arco A, Palomino J, Nuño E, Lomas J M, Natera C, Fajardo J M, Delgado J, Torres-Tortosa M, Romero A, Martín-Rico P, Muniain M Á, Rodríguez-Baño J
Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Avda. Dr. Fedriani 3, 41009, Sevilla, Spain,
Eur J Clin Microbiol Infect Dis. 2014 Aug;33(8):1439-48. doi: 10.1007/s10096-014-2091-1. Epub 2014 Mar 27.
Hip hemiarthroplasty (HHA) and total hip arthroplasty (THA) infections are usually considered as one entity; however, they may show important differences. We analyze these differences, as well as predictors of treatment failure (TF) and poor functional status among patients with prosthetic hip infections (PHIs). A multicenter cohort study of consecutive patients with PHIs was performed. The main outcome variable was TF after the first surgical treatment performed to treat the infection. Multivariate analysis was used to identify predictors of TF. A total of 127 patients with PHI were included (43 HHA, 84 THA). Patients with HHA infections were more frequently women (88% vs. 54%; p < 0.001), had comorbidities (86% vs. 67%, p = 0.02), and were older (median age 79 vs. 65 years, p < 0.001), and the reason for arthroplasty was more frequently a fracture (100% vs. 18%, p < 0.001). Failure of initial treatment and crude mortality were more frequent among HHA patients (44% vs. 23%, p = 0.01 and 28% vs. 7%, p = 0.001, respectively). However, HHA was not associated with TF in the multivariate analysis when hip fracture was considered; thus, variables independently associated with TF were hip fracture, inadequate surgical management, prosthesis retention, and higher C-reactive protein level. Failure of the first surgical treatment was associated with poorer functional status. HHA and THA infections showed significant differences in epidemiology, clinical features, and outcome. Although patients with HHA infections had a higher risk of TF, this was related to the reason for hip implant: a hip fracture. Success of the initial management of infection is a predictor of better clinical and functional outcome.
髋关节半关节置换术(HHA)和全髋关节置换术(THA)感染通常被视为同一类情况;然而,它们可能存在重要差异。我们分析了这些差异,以及人工髋关节感染(PHIs)患者治疗失败(TF)和功能状态不佳的预测因素。对连续的PHIs患者进行了一项多中心队列研究。主要结局变量是首次治疗感染的手术治疗后的TF。采用多变量分析来确定TF的预测因素。共纳入127例PHI患者(43例HHA,84例THA)。HHA感染患者女性更为常见(88%对54%;p<0.001),有合并症(86%对67%,p=0.02),且年龄更大(中位年龄79岁对65岁,p<0.001),关节置换的原因更常见于骨折(100%对18%,p<0.001)。HHA患者初始治疗失败和粗死亡率更高(分别为44%对23%,p=0.01和28%对7%,p=0.001)。然而,在多变量分析中,当考虑髋部骨折时,HHA与TF无关;因此,与TF独立相关的变量是髋部骨折、手术处理不当、假体保留和较高的C反应蛋白水平。首次手术治疗失败与较差的功能状态相关。HHA和THA感染在流行病学、临床特征和结局方面存在显著差异。尽管HHA感染患者TF风险较高,但这与髋部植入物的原因有关:髋部骨折。感染初始管理的成功是更好的临床和功能结局的预测因素。