Shah V R, Butala B P, Parikh G P, Vora K S, Parikh B K, Modi M P, Bhosale G P, Mehta T
Department of Anesthesia, Institute of Kidney Diseases and Research Center and Institute of Transplantation, Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat, India.
Transplant Proc. 2008 Dec;40(10):3451-4. doi: 10.1016/j.transproceed.2008.06.065.
Appropriate anesthesia for pediatric renal transplantation requires stable intraoperative hemodynamics, optimal perfusion of the newly transplanted kidney and good analgesia during recovery. The aim of this study was to assess the preliminary application, success and safety of combined epidural and general anesthesia in pediatric renal transplantation in a small cohort.
We retrospectively reviewed the anesthesia records of 46 consecutive pediatric patients who received renal transplantation under combined epidural and general anesthesia from January 2003-2007.
The mean patient age and weight were 13.2 +/- 2.4 years and 25.7 +/- 5.46 kg, respectively. The infused crystalloids, 20% albumin and red blood cell concentrates were 120 +/- 2 mL/kg to achieve a CVP of 13 to 15 mm Hg. Brisk diuresis was observed in all patients. Epidural tramadol (2 mg/kg) provided good postoperative analgesia in 89% patients. 15% patients developed radiological evidence of pulmonary edema, only one required mechanical ventilation for hypoxemia. Minor adverse effects were nausea and vomiting (17.5%) and convulsions (8.5%). No perioperative mortality or major morbidity was recorded.
Epidural anesthesia is a useful adjunct to general anesthesia due to stable intraoperative haemodynamics and good postoperative analgesia.
小儿肾移植的合适麻醉需要术中血流动力学稳定、新移植肾脏的最佳灌注以及恢复期间良好的镇痛效果。本研究的目的是评估在一小群小儿肾移植患者中联合硬膜外麻醉和全身麻醉的初步应用、成功率及安全性。
我们回顾性分析了2003年1月至2007年期间连续46例接受联合硬膜外麻醉和全身麻醉下肾移植的小儿患者的麻醉记录。
患者的平均年龄和体重分别为13.2±2.4岁和25.7±5.46千克。输注晶体液、20%白蛋白和红细胞浓缩液的量为120±2毫升/千克,以使中心静脉压达到13至15毫米汞柱。所有患者均出现明显利尿。硬膜外注射曲马多(2毫克/千克)使89%的患者术后镇痛良好。15%的患者出现肺水肿的影像学证据,仅1例因低氧血症需要机械通气。轻微不良反应为恶心和呕吐(17.5%)及惊厥(8.5%)。未记录围手术期死亡或严重并发症。
由于术中血流动力学稳定和术后镇痛良好,硬膜外麻醉是全身麻醉的有用辅助手段。