De Simone P, Coletti L, Campani D, Falcone A, Filipponi F
Liver Transplant Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.
Transplant Proc. 2008 Dec;40(10):3821-2. doi: 10.1016/j.transproceed.2008.06.080.
Sinonasal undifferentiated carcinoma (SNUC) is a relatively newly described malignancy of the nasal cavity and paranasal sinuses with a reported 25% to 30% risk for distant metastases. We have reported herein the case of a patient who underwent orthotopic liver transplantation (OLT) for hepatic metastases of SNUC. At 13 months follow-up she is alive with no sign of local or distant-site recurrence. Despite the limited follow-up, the present case suggests that a long disease-free survival after primary surgery, absence of local-regional recurrence, and stability of disease after chemotherapy may represent selection criteria to refer patients for OLT. However, continued follow-up and larger series are necessary to test this hypothesis in the long-term and to assess the role of posttransplantation chemotherapy.
