Yazici Aylin, Naiboglu Baris, Oysu Cagatay, Toros Sema Zer, Noseri Hulya, Karaca Cigdem Tepe, Egeli Erol
Haydarpasa Numune Education and Research Hospital Istanbul, Istanbul, Turkey.
Int J Pediatr Otorhinolaryngol. 2009 Feb;73(2):301-5. doi: 10.1016/j.ijporl.2008.10.021. Epub 2008 Dec 19.
To examine the potential of ototopical ciprofloxacin-dexamethasone (CDX) to delay the closure of myringotomy perforation and to evaluate its effect on inflammation.
Prospective, randomized, and controlled.
Effusion is obtained in the right middle ear of 24 rats by blocking nasopharyngeal opening of eustachian tube by fibrin glue. Left middle ears of 30 rats remained healthy. Animals were randomly classified into three groups; each containing eight right ears with effusion and 10 rats with healthy left ear. Bilateral myringotomy was applied to all rats and randomly divided into three groups. First group received CDX, second group received serum physiologic (SF) for 14 days. Third group served as control. Otomicroscopy was performed by days 7, 14 and 28 to assess wound healing. On day of 28, all animals were humanly euthanized in order to pathological examination of the tympanic bullas.
CDX group showed lesser perforation closure ratios both in healthy and diseased ears. Inflammation was found to be lesser at CDX group in comparison to other groups.
Closure of the myringotomy perforation can be modulated by ototopical CDX treatment. This delaying of wound healing may be attributed to antiinflammatory action of dexamethasone.
研究耳用环丙沙星-地塞米松（CDX）延缓鼓膜切开术穿孔闭合的可能性，并评估其对炎症的影响。
前瞻性、随机对照研究。
通过用纤维蛋白胶封闭24只大鼠右侧中耳的咽鼓管咽口来获取中耳积液。30只大鼠的左侧中耳保持健康。将动物随机分为三组；每组包含8只右侧有积液的耳朵和10只左侧健康的耳朵。对所有大鼠进行双侧鼓膜切开术，并随机分为三组。第一组接受CDX治疗，第二组接受14天的生理盐水（SF）治疗。第三组作为对照组。在第7天、14天和28天进行耳显微镜检查以评估伤口愈合情况。在第28天，对所有动物实施安乐死以便对鼓泡进行病理检查。
CDX组在健康耳和患病耳中的穿孔闭合率均较低。与其他组相比，CDX组的炎症较轻。
耳用CDX治疗可调节鼓膜切开术穿孔的闭合。伤口愈合的延迟可能归因于地塞米松的抗炎作用。
