Uneri Cüneyd, Sari Murat, Akboğa Jülide, Yüksel Meral
Departments of Otorhinolaryngology, Head and Neck Surgery, Marmara University School of Medicine, Istanbul, Turkey.
Laryngoscope. 2006 Jan;116(1):140-3. doi: 10.1097/01.mlg.0000191460.32862.bf.
Tympanosclerosis is a common sequela of ventilation tube treatment of otitis media with effusion causing hearing disability. It is associated with an increased production of free radicals (also known as reactive oxygen species) after myringotomy. Vitamin E is a scavenger of different free radicals by working as an antioxidant. The aim of the present study was to evaluate the effect of vitamin E-coated tympanostomy tube insertion at quantity of free radicals in rat tympanic membrane.
This prospective, controlled animal study consisted of male Sprague-Dawley rats divided into two groups of 10 animals each. Ordinary silcone tubes were applied to the right ears of the first group and vitamin E-coated silcone tubes were applied to the right ears of the second group. The left ears were used as controls. Then, the animals were killed and chemiluminescence measurements were made for tympanic membranes.
Reactive oxygen species levels (ROS) were significantly increased in right ears of the first group when compared with the control ears (P < .0001), and the levels were statistically significant decreased in right ears of the second group as compared with the operated ears of the first group (P < .0001). The free radical levels of right and left ears in the second group were similar.
Our results indicate that vitamin E-coated tube insertion decreases the quantity of reactive oxygen species in tympanic membrane after myringotomy and tympanostomy tube insertion.
鼓室硬化症是分泌性中耳炎通气管治疗导致听力残疾的常见后遗症。它与鼓膜切开术后自由基（也称为活性氧）产生增加有关。维生素E作为抗氧化剂，是不同自由基的清除剂。本研究的目的是评估插入维生素E涂层鼓膜造孔管对大鼠鼓膜中自由基数量的影响。
这项前瞻性对照动物研究包括雄性Sprague-Dawley大鼠，分为两组，每组10只动物。第一组右耳插入普通硅胶管，第二组右耳插入维生素E涂层硅胶管。左耳用作对照。然后，处死动物并对鼓膜进行化学发光测量。
与对照耳相比，第一组右耳的活性氧水平（ROS）显著升高（P < .0001），与第一组手术耳相比，第二组右耳的活性氧水平显著降低（P < .0001）。第二组左右耳的自由基水平相似。
我们的结果表明，插入维生素E涂层管可降低鼓膜切开术和鼓膜造孔管插入术后鼓膜中的活性氧数量。
