Zingone Bartolo, Gatti Giuseppe, Rauber Elisabetta, Tiziani Paola, Dreas Lorella, Pappalardo Aniello, Benussi Bernardo, Spina Amedeo
Division of Cardiac Surgery, Ospedali Riuniti di Trieste, Trieste, Italy.
Ann Thorac Surg. 2009 Jan;87(1):71-8. doi: 10.1016/j.athoracsur.2008.10.011.
Expanding demand for cardiac surgery in the elderly requires constant assessment of selection criteria and outcomes.
Records of consecutive patients 80 years old or greater (n = 355) having cardiac operations from September 1998 through May 2007 were reviewed. There were 172 isolated coronary bypass grafting (CABG), 73 isolated valve, 79 valve and CABG combined, and 31 other procedures.
Thirty-three (9.3%) deaths and 13 (3.7%) strokes occurred during the index hospital stay. Intensive care unit and hospital length of stay lasted 6.3 +/- 14.3 and 15.5 +/- 20.8 days, respectively. Overall cumulative 5-year survival was 65.5 +/- 3.3%, varying among procedures as follows: 67.9 +/- 4.4% for isolated CABG, 64.6 +/- 8.9% for valve surgery, 60.3 +/- 7.3% for combined coronary and valve surgery, and 63 +/- 10.7% for other procedures (p = 0.23). Ninety-seven percent of survivors lived at home. Risk factors for hospital death were emergency status, preoperative renal dysfunction, and postoperative complications such as myocardial infarction, cardiac failure requiring intraaortic balloon pumping, acute renal failure requiring replacement therapy, stroke, and ventilator dependency exceeding 48 hours. Among hospital survivors, risk factors for late death were carotid artery disease, chronic lung disease, renal dysfunction, and the occurrence of postoperative complications.
Long-term survival of octogenarians submitted to a wide variety of cardiac operations was satisfactory despite substantial rates of early complications and deaths. Most survivors were free from cardiac symptoms. Postoperative complications were stronger risk factors for hospital deaths than preoperative comorbidities and procedural variables. Their impact on long-term survival was also significant.
老年人心脏手术需求不断增加,需要持续评估选择标准和手术结果。
回顾了1998年9月至2007年5月期间连续接受心脏手术的80岁及以上患者(n = 355)的记录。其中有172例单纯冠状动脉旁路移植术(CABG),73例单纯瓣膜手术,79例瓣膜手术与CABG联合手术,以及31例其他手术。
在首次住院期间发生33例(9.3%)死亡和13例(3.7%)中风。重症监护病房和住院时间分别为6.3±14.3天和15.5±20.8天。总体累积5年生存率为65.5±3.3%,不同手术的生存率如下:单纯CABG为67.9±4.4%,瓣膜手术为64.6±8.9%,冠状动脉和瓣膜联合手术为60.3±7.3%,其他手术为63±10.7%(p = 0.23)。97%的幸存者在家中生活。医院死亡的危险因素包括急诊状态、术前肾功能不全以及术后并发症,如心肌梗死、需要主动脉内球囊反搏的心力衰竭、需要替代治疗的急性肾功能衰竭、中风以及呼吸机依赖超过48小时。在医院幸存者中,晚期死亡的危险因素包括颈动脉疾病、慢性肺病、肾功能不全以及术后并发症的发生。
尽管早期并发症和死亡率较高,但接受各种心脏手术的八旬老人的长期生存率令人满意。大多数幸存者没有心脏症状。术后并发症是医院死亡比术前合并症和手术变量更强的危险因素。它们对长期生存的影响也很显著。