Freire-Garabal M, Balboa J L, Núñez M J, Castaño M T, Llovo J B, Fernández-Rial J C, Belmonte A
Department of Pharmacology, School of Medicine, University of Santiago de Compostela, Spain.
Life Sci. 1991;49(16):PL107-12. doi: 10.1016/0024-3205(91)90570-2.
Mice chronically injected with amphetamine (0.4 mg/kg/day) showed a reduction in thymus and spleen cellularity, and in peripheral T lymphocyte population. The blastogenic response of spleen lymphoid cells was assessed and amphetamine was found to inhibit T-cell proliferation. Amphetamine also reduced the capacity of mice to the development and passive transfer of immunity to Listeria monocytogenes.
长期注射苯丙胺（0.4毫克/千克/天）的小鼠胸腺和脾脏细胞数量减少，外周T淋巴细胞数量也减少。对脾脏淋巴样细胞的增殖反应进行了评估，发现苯丙胺可抑制T细胞增殖。苯丙胺还降低了小鼠对单核细胞增生李斯特菌免疫的发育和被动转移能力。
