Srinivasan Narasimhan, Kavitha Mahendran, Loganathan Chandarasekaran S, Padmini Govindasamy
Department of Conservative Dentistry, Tamilnadu Government Dental College and Hospital, Chennai-3, India.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Jan;107(1):133-6. doi: 10.1016/j.tripleo.2008.09.002.
The purpose of this prospective, randomized, double-blind study was to compare the anesthetic efficacy of 4% articaine and 2% lidocaine (both with 1:100,000 epinephrine) for buccal infiltration in patients experiencing irreversible pulpitis in maxillary posterior teeth.
Forty patients with irreversible pulpitis in first premolar or first molar were divided into 4 study groups and received buccal infiltration of either 4% articaine or 2% lidocaine in a double-blind manner. Endodontic access was begun 5 minutes after solution deposition. Success was defined as no or mild discomfort (VAS recordings) during the endodontic procedure.
The success rate for maxillary buccal infiltration to produce pulpal anesthesia using articaine was 100% in first premolar and first molar, and for the lidocaine solution, success rate was 80% in first premolar and 30% in first molar. There was high significant difference between the articaine and lidocaine solutions (ANOVA; P < .001).
The efficacy of 4% articaine was superior to 2% lidocaine for maxillary buccal infiltration in posterior teeth.
本前瞻性、随机、双盲研究的目的是比较4%阿替卡因和2%利多卡因（均含1:100,000肾上腺素）对上颌后牙不可逆性牙髓炎患者进行颊侧浸润麻醉的效果。
40例第一前磨牙或第一磨牙患有不可逆性牙髓炎的患者被分为4个研究组，以双盲方式接受4%阿替卡因或2%利多卡因的颊侧浸润。在溶液注入5分钟后开始开髓。成功定义为在牙髓治疗过程中无不适或轻度不适（视觉模拟量表记录）。
使用阿替卡因进行上颌颊侧浸润产生牙髓麻醉的成功率在第一前磨牙和第一磨牙中均为100%，而利多卡因溶液在第一前磨牙中的成功率为80%，在第一磨牙中为30%。阿替卡因溶液和利多卡因溶液之间存在高度显著差异（方差分析；P <.001）。
4%阿替卡因在上颌后牙颊侧浸润麻醉的效果优于2%利多卡因。
