Department of Periodontology, Islamic International Dental College and Hospital, Riphah International University, Islamabad 44000, Pakistan.
Department of Operative Dentistry, Islamic International Dental College and Hospital, Riphah International University, Islamabad 44000, Pakistan.
Medicina (Kaunas). 2023 Oct 16;59(10):1840. doi: 10.3390/medicina59101840.
: Lidocaine Hydrochloride has been the standard choice for local anesthesia in dentistry and Articaine's unique structure and growing popularity make it a viable alternative. Due to contradictory results in prior research and a scarcity of trials conducted in the Pakistani population, this study aims to compare the anesthetic efficacy of Lidocaine with Articaine for inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis. : This double-blinded, randomized controlled trial included 152 patients who were selected by consecutive non-probability sampling. The participants included patients who presented with symptomatic irreversible pulpitis in mandibular posterior teeth (molars and premolars) and depicted normal apical tissue radiographically. The patients were equally and randomly divided into two groups. The control group received 2% Lidocaine Hydrochloride injections, and the experiment group received 4% Articaine Hydrochloride injections. Participants scored their pain on the HP-VAS both before and after the administration of anesthesia. A value of 54 mm or less on the scale indicated effective anesthesia. The data obtained were analyzed using SPSS. Chi-square test was applied to analyze data for statistical significance. : There was no statistically significant difference in the efficacy of the two anesthetic agents. During access cavity preparation, Lidocaine demonstrated a success rate of 93%, whereas Articaine exhibited a slightly higher success rate of 97%. During initial instrumentation, the success rates for Lidocaine and Articaine were 72% and 71%, respectively. This suggests that both Lidocaine and Articaine were effective in achieving anesthesia during the dental procedure in patients with symptomatic irreversible pulpitis, with Articaine showing a slightly better success rate, although the difference was not statistically significant. : The anesthetic efficacy of Articaine is similar to that of lidocaine in subjects with symptomatic irreversible pulpitis. Hence, Articaine can serve as an alternative to Lidocaine for local anesthesia administration in dentistry.
盐酸利多卡因一直是牙科局部麻醉的标准选择，而阿替卡因的独特结构和日益普及使其成为一种可行的替代品。由于先前研究的结果存在矛盾，且在巴基斯坦人群中进行的试验稀缺，本研究旨在比较利多卡因和阿替卡因在下颌牙槽神经阻滞中用于有症状不可复性牙髓炎患者的麻醉效果。
这是一项双盲、随机对照试验，纳入了通过连续非概率抽样选择的 152 名患者。参与者包括以下患者：下颌后牙（磨牙和前磨牙）出现有症状不可复性牙髓炎，且根尖组织影像学正常。患者被平均随机分为两组。对照组接受 2%盐酸利多卡因注射，实验组接受 4%盐酸阿替卡因注射。参与者在麻醉给药前后使用 HP-VAS 对疼痛进行评分。评分在 54 毫米或以下表示麻醉有效。使用 SPSS 分析获得的数据。采用卡方检验分析数据的统计学意义。
两种麻醉剂的疗效无统计学差异。在制备开髓洞时，利多卡因的成功率为 93%，而阿替卡因的成功率略高，为 97%。在初次器械预备时，利多卡因和阿替卡因的成功率分别为 72%和 71%。这表明在有症状不可复性牙髓炎患者的牙科手术中，利多卡因和阿替卡因都能有效地实现麻醉，阿替卡因的成功率略高，但差异无统计学意义。
阿替卡因在有症状不可复性牙髓炎患者中的麻醉效果与利多卡因相似。因此，阿替卡因可作为利多卡因在牙科局部麻醉中的替代药物。
