Gogvadze Vladimir, Orrenius Sten, Zhivotovsky Boris
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Semin Cancer Biol. 2009 Feb;19(1):57-66. doi: 10.1016/j.semcancer.2008.11.007. Epub 2008 Dec 3.
Heterogeneity of tumors dictates an individual approach to anticancer treatment. Despite their variability, almost all cancer cells demonstrate enhanced uptake and utilization of glucose, a phenomenon known as the Warburg effect, whereas mitochondrial activity in tumor cells is suppressed. Considering the key role of mitochondria in cell death, it appears that resistance of most tumors towards treatment can be, at least in part, explained by mitochondrial silencing in cancer cells. This review is devoted to the role of mitochondria in cell death, and describes how targeting of mitochondria can make tumor cells more susceptible to anticancer treatment.
肿瘤的异质性决定了抗癌治疗需采取个体化方法。尽管肿瘤细胞具有变异性，但几乎所有癌细胞都表现出对葡萄糖摄取和利用的增强，这一现象被称为瓦伯格效应，而肿瘤细胞中的线粒体活性则受到抑制。鉴于线粒体在细胞死亡中的关键作用，似乎大多数肿瘤对治疗的抗性至少部分可以通过癌细胞中的线粒体沉默来解释。本综述致力于探讨线粒体在细胞死亡中的作用，并描述靶向线粒体如何使肿瘤细胞更容易受到抗癌治疗的影响。
