Lim Sun Min, Kim Hyeon Chang, Lee Hoon Sang, Lee Joo Young, Suh Mina, Ahn Song Vogue
Severance Hospital, Yonsei University Health System, Seoul, Korea.
J Pediatr. 2009 May;154(5):667-71. doi: 10.1016/j.jpeds.2008.10.047. Epub 2008 Dec 21.
To investigate the association between blood pressure and carotid intima-media thickness (IMT) in healthy adolescents.
Study participants included 285 first-year high school students (mean age, 15.2 years) at a rural high school in Korea. Systolic and diastolic blood pressure (SBP and DBP) were measured with an oscillometric automated sphygmomanometer. The carotid arteries were evaluated with high-resolution B-mode ultrasound scanning. IMT value was determined with the average of the maximal IMT at each common carotid artery. Increased IMT was defined as sex-specific top quartile. The odds ratio (OR) for increased IMT per 1 SD increase of SBP and DBP was estimated after adjusting for age, sex, body mass index, waist circumference, fasting glucose level, and total/high-density lipoprotein cholesterol ratio.
Adjusted OR for increased IMT was 1.70 (P = .003) per 12.4 mm Hg SBP and 1.25 (P = .125) per 7.0 mm Hg DBP. When the analyses were performed by sex, increased IMT was associated with both SBP (OR, 2.67; P = .003) and DBP (OR, 1.68; P = .019) in girls, but it was not associated with either SBP (OR, 1.46; P = .093) or DBP (OR, 0.99; P = .972) in boys.
These results suggest that higher blood pressure level may be associated with increased carotid IMT in apparently healthy adolescents.
探讨健康青少年血压与颈动脉内膜中层厚度（IMT）之间的关联。
研究参与者包括韩国一所农村高中的285名高一学生（平均年龄15.2岁）。使用示波自动血压计测量收缩压和舒张压（SBP和DBP）。通过高分辨率B型超声扫描评估颈动脉。IMT值通过每条颈总动脉最大IMT的平均值来确定。IMT增加定义为按性别划分的上四分位数。在调整年龄、性别、体重指数、腰围、空腹血糖水平以及总胆固醇/高密度脂蛋白胆固醇比值后，估计SBP和DBP每升高1个标准差时IMT增加的比值比（OR）。
调整后，SBP每升高12.4 mmHg时IMT增加的OR为1.70（P = 0.003），DBP每升高7.0 mmHg时IMT增加的OR为1.25（P = 0.125）。按性别进行分析时，女孩中IMT增加与SBP（OR，2.67；P = 0.003）和DBP（OR，1.68；P = 0.019）均相关，但男孩中IMT增加与SBP（OR，1.46；P = 0.093）或DBP（OR，0.99；P = 0.972）均无关联。
这些结果表明，在看似健康的青少年中，较高的血压水平可能与颈动脉IMT增加有关。
