用于合成轴手性联芳基的过渡金属催化对映选择性[2+2+2]环加成反应。
Transition-metal-catalyzed enantioselective [2+2+2] cycloadditions for the synthesis of axially chiral biaryls.
作者信息
Tanaka Ken
机构信息
Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan.
出版信息
Chem Asian J. 2009 Apr 6;4(4):508-18. doi: 10.1002/asia.200800378.
Recent advances towards a development of novel transition-metal-catalyzed enantioselective [2+2+2] cycloadditions for the synthesis of axially chiral biaryls are reviewed. A number of efficient enantioselective biaryl syntheses were accomplished by chiral cobalt(I), iridium(I), and rhodium(I) complex catalyzed [2+2+2] cycloadditions. Furthermore, the enantioselective synthesis of axially chiral biaryls possessing non-biaryl axial chirality was also developed by using chiral rhodium(I) complexes as catalysts.
综述了新型过渡金属催化对映选择性[2+2+2]环加成反应在轴向手性联芳基合成方面的最新进展。通过手性钴（I）、铱（I）和铑（I）配合物催化的[2+2+2]环加成反应，实现了多种高效的对映选择性联芳基合成。此外，还开发了以手性铑（I）配合物为催化剂，对具有非联芳基轴向手性的轴向手性联芳基进行对映选择性合成的方法。
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