铑（I）催化的烯炔酰胺[2 + 2 + 2]环加成反应在酰胺取代的手性联芳基合成中的应用
Rhodium(I)-catalyzed [2 + 2 + 2] cycloadditions of ynamides in the synthesis of amide-substituted chiral biaryls.
作者信息
Tracey Michael R, Oppenheimer Jossian, Hsung Richard P
机构信息
Division of Pharmaceutical Sciences and Department of Chemistry, Rennebohm Hall, 777 Highland Avenue, University of Wisconsin, Madison, Wisconsin 53705, USA.
出版信息
J Org Chem. 2006 Oct 27;71(22):8629-32. doi: 10.1021/jo061683p.
PMID:17064045
Abstract
Rhodium(I)-catalyzed [2 + 2 + 2] cycloadditions of sterically encumbered aryl-substituted ynamides with various diynes are described here. These cycloadditions provide the synthesis of an array of new chiral amide-substituted biaryls that can be useful in future chiral ligand designs.
摘要
本文描述了铑（I）催化的空间位阻芳基取代炔酰胺与各种二炔的[2 + 2 + 2]环加成反应。这些环加成反应可用于合成一系列新型手性酰胺取代的联芳基化合物，这些化合物在未来的手性配体设计中可能会有用。
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