Kram J, Bölter C, Graf B, Urbaszek W
Abteilung für Kardiologie, Universität Rostock.
Z Gesamte Inn Med. 1991 May;46(7):223-8.
In 16 patients with unstable angina pectoris haemodynamic and clinical effects of diltiazem were investigated. In a second group patients (n = 11) with unstable or therapy-refractory course the long-term effect was tested. The acute intervention with injected and infused diltiazem via an improved oxygen balance due to decreased minute work and reduced product of cardiac frequency and pressure stabilized the clinical picture from the haemodynamic aspect. The decreases of the ST segment were significantly lower. In the long-term use a significant influence on the frequency of angina pectoris with increase of the range of efficacy by one NYHA-state was the result. Diltiazem can be regarded as alternative medicament in unstable phases and in therapy-refractory courses of the chronic coronary heart disease.
对16例不稳定型心绞痛患者研究了地尔硫䓬的血流动力学及临床效果。在第二组患者（n = 11）中，这些患者病程不稳定或对治疗抵抗，对其进行了长期效果测试。通过静脉注射和输注地尔硫䓬进行急性干预，由于每分功降低以及心率与血压乘积减少，氧平衡得到改善，从血流动力学方面稳定了临床症状。ST段下降幅度明显降低。长期使用地尔硫䓬的结果是对心绞痛发作频率有显著影响，疗效范围提高了一个纽约心脏协会（NYHA）分级。地尔硫䓬可被视为慢性冠心病不稳定期及治疗抵抗病程中的替代药物。
