Dwivedi S, Agarwal M P
Department of Medicine, UCMS, Delhi.
J Assoc Physicians India. 1994 Apr;42(4):287-9.
The effect of bark powder of Terminalia arjuna, an indigenous drug, on anginal frequency, blood pressure, body mass index, blood sugar, cholesterol and HDL-cholesterol was studied in 15 stable (Group A) and 5 unstable (Group B) angina patients before and 3 months after T. arjuna therapy. Tread mill test (TMT) and echocardiographic left ventricular ejection fraction was evaluated in some cases. There was 50% reduction in anginal episodes in Group A cases (P < 0.01). TMT performance improved from moderate to mild changes in 5 patients and one with mild changes became negative for ischemia. The time to the onset of angina and appearance of ST-T changes on TMT after T. arjuna was delayed significantly. However, in patients with unstable angina there was an insignificant reduction in anginal frequency. These patients also needed diltiazem, B-blockers and nitroglycerine in addition to T. arjuna. The drug lowered systolic blood pressure and body mass index to a significant level (p < 0.05) and increased HDL-cholesterol only slightly along with marginal improvement in left ventricular ejection fraction in stable angina patients. There were no deleterious effects on liver or kidney functions. Our results suggest that monotherapy with T. arjuna is fairly effective in patients with symptoms of stable angina pectoris. However, it has a limited role in unstable angina.
在15例稳定型心绞痛患者（A组）和5例不稳定型心绞痛患者（B组）中，研究了印度本土药物阿朱那诃子树皮粉在治疗前及治疗3个月后对心绞痛发作频率、血压、体重指数、血糖、胆固醇和高密度脂蛋白胆固醇的影响。部分病例进行了平板运动试验（TMT）和超声心动图评估左心室射血分数。A组病例心绞痛发作次数减少了50%（P<0.01）。5例患者的平板运动试验表现从中度改善为轻度改变，1例轻度改变患者的缺血情况变为阴性。服用阿朱那诃子后，心绞痛发作时间和平板运动试验中ST-T改变出现的时间显著延迟。然而，不稳定型心绞痛患者的心绞痛发作频率虽有下降，但不显著。除阿朱那诃子外，这些患者还需要使用地尔硫䓬、β受体阻滞剂和硝酸甘油。该药物可使收缩压和体重指数显著降低（p<0.05），仅轻微升高高密度脂蛋白胆固醇，同时稳定型心绞痛患者的左心室射血分数略有改善。对肝肾功能无不良影响。我们的结果表明，阿朱那诃子单一疗法对稳定型心绞痛患者症状相当有效。然而，它在不稳定型心绞痛中的作用有限。
