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1
Is there an association between fibromyalgia and below-normal levels of urinary cortisol?纤维肌痛与尿皮质醇水平低于正常之间是否存在关联？
BMC Res Notes. 2008 Dec 22;1:134. doi: 10.1186/1756-0500-1-134.
2
[Evaluation of urinary cortisol levels in women with fibromyalgia].
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3
Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia.纤维肌痛患者下丘脑-垂体-肾上腺轴功能紊乱
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Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgia.纤维肌痛患者皮质醇分泌与症状之间的瞬间关系。
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J Rheumatol. 1998 Jul;25(7):1374-81.
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Hypothalamic-pituitary-gonadal axis and cortisol in young women with primary fibromyalgia: the potential roles of depression, fatigue, and sleep disturbance in the occurrence of hypocortisolism.原发性纤维肌痛年轻女性的下丘脑-垂体-性腺轴与皮质醇：抑郁、疲劳和睡眠障碍在低皮质醇血症发生中的潜在作用
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Hum Reprod. 2015 Jun;30(6):1460-72. doi: 10.1093/humrep/dev086. Epub 2015 Apr 22.

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A theoretical framework to improve the construct for chronic pain disorders using fibromyalgia as an example.以纤维肌痛为例，用于改进慢性疼痛疾病结构的理论框架。
Ther Adv Musculoskelet Dis. 2021 Jan 28;13:1759720X20966490. doi: 10.1177/1759720X20966490. eCollection 2021.
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Ther Adv Musculoskelet Dis. 2018 Jan;10(1):13-26. doi: 10.1177/1759720X17740076. Epub 2017 Dec 7.
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Assessing the prevalence of autoimmune, endocrine, gynecologic, and psychiatric comorbidities in an ethnically diverse cohort of female fibromyalgia patients: does the time from hysterectomy provide a clue?评估不同种族女性纤维肌痛患者队列中自身免疫性、内分泌、妇科和精神共病的患病率：子宫切除术后的时间是否能提供线索？
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An eight-week yoga intervention is associated with improvements in pain, psychological functioning and mindfulness, and changes in cortisol levels in women with fibromyalgia.一项为期八周的瑜伽干预与纤维肌痛女性的疼痛、心理功能和正念改善以及皮质醇水平变化相关。
J Pain Res. 2011;4:189-201. doi: 10.2147/JPR.S22761. Epub 2011 Jul 26.

本文引用的文献

1
[Not Available].[无可用内容]。
Reumatol Clin. 2006 Mar;2 Suppl 1:S55-66. doi: 10.1016/S1699-258X(06)73084-4. Epub 2008 Dec 10.
2
Serum serotonin levels are not useful in diagnosing fibromyalgia.血清血清素水平对纤维肌痛的诊断没有帮助。
Ann Rheum Dis. 2007 Sep;66(9):1267-8. doi: 10.1136/ard.2006.058842.
3
Fibromyalgia syndrome.纤维肌痛综合征
J Rheumatol. 2007 Jun;34(6):1415-25.
4
Is further evaluation for growth hormone (GH) deficiency necessary in fibromyalgia patients with low serum insulin-like growth factor (IGF)-I levels?血清胰岛素样生长因子（IGF）-I水平低的纤维肌痛患者是否需要对生长激素（GH）缺乏进行进一步评估？
Growth Horm IGF Res. 2007 Feb;17(1):82-8. doi: 10.1016/j.ghir.2006.12.006. Epub 2007 Feb 6.
5
Growth hormone perturbations in fibromyalgia: a review.纤维肌痛中的生长激素紊乱：综述
Semin Arthritis Rheum. 2007 Jun;36(6):357-79. doi: 10.1016/j.semarthrit.2006.09.006. Epub 2007 Jan 16.
6
Fibromyalgia syndrome.纤维肌痛综合征
J Rheumatol. 2005 Nov;32(11):2270-7.
7
Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgia.纤维肌痛患者皮质醇分泌与症状之间的瞬间关系。
Arthritis Rheum. 2005 Nov;52(11):3660-9. doi: 10.1002/art.21372.
8
Hypothalamic-pituitary-gonadal axis and cortisol in young women with primary fibromyalgia: the potential roles of depression, fatigue, and sleep disturbance in the occurrence of hypocortisolism.原发性纤维肌痛年轻女性的下丘脑-垂体-性腺轴与皮质醇：抑郁、疲劳和睡眠障碍在低皮质醇血症发生中的潜在作用
Ann Rheum Dis. 2004 Nov;63(11):1504-6. doi: 10.1136/ard.2003.014969.
9
[Problems in diagnosing fibromyalgia].[纤维肌痛诊断中的问题]
Aten Primaria. 2004 May 31;33(9):526-7. doi: 10.1016/s0212-6567(04)70832-x.
10
Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndrome.纤维肌痛和/或慢性疲劳综合征患者的基础昼夜节律性及脉冲性促肾上腺皮质激素和皮质醇分泌
Brain Behav Immun. 2004 Jul;18(4):314-25. doi: 10.1016/j.bbi.2003.12.011.

纤维肌痛与尿皮质醇水平低于正常之间是否存在关联？

Is there an association between fibromyalgia and below-normal levels of urinary cortisol?

作者信息

Izquierdo-Alvarez Silvia, Bocos-Terraz Julia Pilar, Bancalero-Flores Jose Luis, Pavón-Romero Lenin, Serrano-Ostariz Enrique, de Miquel Cayetano Alegre

机构信息

Department of Biochemistry (Hormonal Section), Hospital Universitario Miguel Servet, Zaragoza, Spain.

出版信息

BMC Res Notes. 2008 Dec 22;1:134. doi: 10.1186/1756-0500-1-134.

DOI:10.1186/1756-0500-1-134
PMID:19102778
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2627911/
Abstract

BACKGROUND

Adynamia in fibromyalgia (FM) may be an expression of a functional deficit of the hypothalamic-pituitary-adrenal axis and be associated with below-normal levels of urinary cortisol. Our aim was to demonstrate that urinary cortisol was lower in patients with FM than in healthy subjects.

FINDINGS

We measured urinary cortisol levels for a sample of 47 women aged 29 to 64 years (mean age 53 years), diagnosed with FM 2-3 years previously, and compared the results with those for a control sample of 58 healthy women of a similar age. Samples of 24-hour urine were appropriately collected and levels of urinary cortisol were measured using the fluorescence polarization immunoassay method. The mean cortisol value for the women with FM was 65.40 +/- 27.10 mug/L, significantly lower than the mean cortisol level for the control group, at 90.83 +/- 38.17 mug/L (p < 0.001).

CONCLUSION

Our study confirms that women with FM have significantly lower urinary cortisol levels than healthy women.

摘要

背景

纤维肌痛（FM）中的肌无力可能是下丘脑 - 垂体 - 肾上腺轴功能缺陷的一种表现，并与尿皮质醇水平低于正常有关。我们的目的是证明FM患者的尿皮质醇水平低于健康受试者。

研究结果

我们测量了47名年龄在29至64岁（平均年龄53岁）的女性样本的尿皮质醇水平，这些女性在2至3年前被诊断为FM，并将结果与58名年龄相仿的健康女性对照样本的结果进行比较。适当收集24小时尿液样本，并使用荧光偏振免疫分析法测量尿皮质醇水平。FM女性的平均皮质醇值为65.40±27.10μg/L，显著低于对照组的平均皮质醇水平90.83±38.17μg/L（p<0.001）。

结论

我们的研究证实，FM女性的尿皮质醇水平显著低于健康女性。