Kumbhare Dinesh, Tesio Luigi
Department of Medicine, Division of Physical Medicine and Rehabilitation, University of Toronto; Pain Research Institute, Toronto Rehabilitation Institute, University Health Network, 550 University Ave, Toronto, ON M5G 2A2, Canada.
Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milano, Italy.
Ther Adv Musculoskelet Dis. 2021 Jan 28;13:1759720X20966490. doi: 10.1177/1759720X20966490. eCollection 2021.
Fibromyalgia (FM) is a frequent, complex condition of chronic musculoskeletal pain with no evidence for biological correlates. For this reason, despite many efforts from the medical community, its construct still appears ill defined. Promising candidate biomarkers are critically reviewed. A research agenda is proposed for developing a clearer construct of FM. The ideal theoretical framework is one of overcoming the illness-disease dichotomy and considering reciprocal interactions between biology and behaviour. This approach may foster research in other fields of pain medicine and of medicine in general.
纤维肌痛（FM）是一种常见的慢性肌肉骨骼疼痛的复杂病症，尚无生物学关联的证据。因此，尽管医学界做出了许多努力，但其概念仍显得定义不明确。对有前景的候选生物标志物进行了严格审查。提出了一项研究议程，以更清晰地构建纤维肌痛的概念。理想的理论框架是克服疾病与病症的二分法，并考虑生物学与行为之间的相互作用。这种方法可能会促进疼痛医学及一般医学其他领域的研究。
