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本文引用的文献

1
Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator.秀丽隐杆线虫的HCF-1作为DAF-16调节因子在维持寿命方面发挥作用。
PLoS Biol. 2008 Sep 30;6(9):e233. doi: 10.1371/journal.pbio.0060233.
2
An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans.一个elt-3/elt-5/elt-6 GATA转录回路指导秀丽隐杆线虫的衰老过程。
Cell. 2008 Jul 25;134(2):291-303. doi: 10.1016/j.cell.2008.05.044.
3
FOXO animal models reveal a variety of diverse roles for FOXO transcription factors.FOXO动物模型揭示了FOXO转录因子的多种不同作用。
Oncogene. 2008 Apr 7;27(16):2345-50. doi: 10.1038/onc.2008.27.
4
The role of FoxO in the regulation of metabolism.FoxO在代谢调节中的作用。
Oncogene. 2008 Apr 7;27(16):2320-36. doi: 10.1038/onc.2008.25.
5
The FoxO code.叉头框O代码。
Oncogene. 2008 Apr 7;27(16):2276-88. doi: 10.1038/onc.2008.21.
6
ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells.ASNA-1在秀丽隐杆线虫和哺乳动物细胞中正向调节胰岛素分泌。
Cell. 2007 Feb 9;128(3):577-87. doi: 10.1016/j.cell.2006.12.031.
7
The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans.14-3-3蛋白FTT-2在秀丽隐杆线虫中调节DAF-16。
Dev Biol. 2007 Jan 1;301(1):82-91. doi: 10.1016/j.ydbio.2006.10.013. Epub 2006 Oct 14.
8
The search for DAF-16/FOXO transcriptional targets: approaches and discoveries.对DAF-16/FOXO转录靶点的探索：方法与发现
Exp Gerontol. 2006 Oct;41(10):910-21. doi: 10.1016/j.exger.2006.06.040. Epub 2006 Aug 24.
9
Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation.通过染色质免疫沉淀鉴定直接控制寿命、代谢和滞育的DAF-16靶标。
Nat Genet. 2006 Feb;38(2):251-7. doi: 10.1038/ng1723. Epub 2005 Dec 25.
10
Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn.Ptf1a决定脊髓背角中γ-氨基丁酸能神经元而非谷氨酸能神经元的细胞命运。
Development. 2005 Dec;132(24):5461-9. doi: 10.1242/dev.02167. Epub 2005 Nov 16.

Combined informatic and expression screen identifies the novel DAF-16 target HLH-13.

作者信息

Liachko Nicole, Davidowitz Rachel, Lee Siu Sylvia

机构信息

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.

出版信息

Dev Biol. 2009 Mar 1;327(1):97-105. doi: 10.1016/j.ydbio.2008.11.019. Epub 2008 Dec 7.

DOI:10.1016/j.ydbio.2008.11.019
PMID:19103192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2804473/
Abstract

Insulin/IGF-signaling (IIS) affects longevity, stress resistance and metabolism in worms, flies, and mammals. The Forkhead transcription factor DAF-16/FOXO is the major downstream effector of IIS and is responsible for the activation and repression of genes that mediate the diverse effects of IIS. We surveyed a set of informatically predicted conserved DAF-16/FOXO target genes and identified the novel DAF-16 direct target hlh-13. hlh-13 is the predicted homolog of the mammalian transcription factor Ptf1a, a critical determinant of pancreatic development. We found that an hlh-13 mutant exits L1 arrest and IIS-dependent dauer diapause faster than control worms, but is not involved in lifespan or resistance to a variety of stresses. Our results have identified a novel DAF-16 target gene and linked its function to known outputs of IIS. Considering the high conservation of IIS in diverse species, our results also hint at an intriguing connection of IIS and Ptf1a in mammals.

摘要