Currey Heather N, Kraemer Brian C, Liachko Nicole F
Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington, United States.
Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, Washington, United States.
MicroPubl Biol. 2023 Aug 3;2023. doi: 10.17912/micropub.biology.000844. eCollection 2023.
Expression of human tau in neurons causes progressive, age-associated loss of motor coordination, selective neurodegeneration, and shortened lifespan. Loss of function (LOF) mutations in the conserved gene protects against progressive motor uncoordination and neurodegeneration in models of tauopathy. To determine whether LOF also protects against shortened lifespan of tau transgenic , we conducted lifespan assays comparing four different alleles of We found that LOF robustly suppresses the shortened lifespan of tau transgenic animals. We also demonstrate that tau transgenic exhibit hyperactive pharyngeal pumping, which is restored by LOF.
人类tau蛋白在神经元中的表达会导致渐进性、与年龄相关的运动协调丧失、选择性神经退行性变以及寿命缩短。保守基因中的功能丧失（LOF）突变可在tau蛋白病模型中预防渐进性运动不协调和神经退行性变。为了确定LOF是否也能预防tau转基因动物的寿命缩短，我们进行了寿命测定，比较了四个不同的等位基因。我们发现LOF能有力地抑制tau转基因动物寿命的缩短。我们还证明，tau转基因动物表现出过度活跃的咽部抽动，而LOF可使其恢复。
