Abraini J H, Tomei C, Rostain J C
Laboratoire de biologie des hautes pressions, CNRS URA 1330, Faculté de médecine nord., Marseille, France.
Ann Physiol Anthropol. 1991 Jul;10(3):183-8. doi: 10.2114/ahs1983.10.183.
When human divers or experimental animals are exposed to high pressure, they develop the High Pressure Neurological Syndrome (HPNS). Male Sprague-Dawley rats were exposed to high pressure in a conventional helium-oxygen breathing mixture to 80 bars. Pressure-induced behavioral motor disturbances including hyperlocomotor activity (HLA), tremor and myoclonia were monitored with a noninvasive piezoelectrical sensor device enabling a without discontinuity long-term analysis. New data were obtained on the development of the HPNS behavioral motor disturbances. Indeed, the present results suggest myoclonia would be more sensitive to constant high pressure exposure, while HLA and tremor would be more sensitive to increasing pressure. Moreover, myoclonia were found to occur significantly later in rats which developed epileptic seizures than in other. The present results constitute the quantitative basis of HPNS motor disturbances for future pharmacological pressure experiments.
当人类潜水员或实验动物暴露于高压环境时，会出现高压神经综合征（HPNS）。将雄性斯普拉格-道利大鼠置于传统的氦氧混合气体中，使其暴露于80巴的高压环境。使用一种无创压电传感器设备监测压力诱导的行为运动障碍，包括运动亢进活动（HLA）、震颤和肌阵挛，该设备能够进行不间断的长期分析。获得了关于HPNS行为运动障碍发展的新数据。事实上，目前的结果表明，肌阵挛对持续高压暴露更敏感，而HLA和震颤对压力升高更敏感。此外，发现发生癫痫发作的大鼠中肌阵挛出现的时间明显晚于其他大鼠。目前的结果构成了未来HPNS运动障碍药理学压力实验的定量基础。
