Abraini J H, Fechtali T
Unité de Neuropsychiatrie, C.H.U. de Sart Tilman, Liège, Belgigue.
Neurosci Biobehav Rev. 1992 Winter;16(4):597-602. doi: 10.1016/s0149-7634(05)80199-x.
When human divers or experimental animals are exposed to high pressure they develop the high pressure neurological syndrome (HPNS). The main symptoms include electroencephalographic changes and behavioral disturbances such as tremor, myoclonia, and hyperlocomotor activity. Recently, pressure-induced disorders in dopaminergic and amino-acidergic neurotransmission have been reported. In the present theoretical study, we review in vitro and in vivo neurochemical, electrophysiological, and pharmacobehavioral evidence concerning alterations in dopaminergic, glutamatergic, and GABAergic transmission occurring at high pressure, and their possible relationship to the symptoms of HPNS. Moreover, we also examine data concerning interactions, at normal pressure, between dopaminergic, glutamatergic, and GABAergic transmission that we suggest they could apply equally under high pressure between the pressure-induced disorders in dopaminergic and amino-acidergic transmission.
当人类潜水员或实验动物暴露于高压环境时，会出现高压神经综合征（HPNS）。主要症状包括脑电图变化以及行为障碍，如震颤、肌阵挛和活动亢进。最近，有报道称高压会引发多巴胺能和氨基酸能神经传递紊乱。在本理论研究中，我们回顾了关于高压下多巴胺能、谷氨酸能和γ-氨基丁酸能神经传递改变的体外和体内神经化学、电生理及药物行为学证据，以及它们与HPNS症状可能存在的关系。此外，我们还研究了在常压下多巴胺能、谷氨酸能和γ-氨基丁酸能神经传递之间相互作用的数据，我们认为这些数据在高压下多巴胺能和氨基酸能神经传递的压力诱导紊乱之间同样适用。
