Towers Matthew, Tickle Cheryll
Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK.
Development. 2009 Jan;136(2):179-90. doi: 10.1242/dev.024158.
The developing limb has been a very influential system for studying pattern formation in vertebrates. In the past, classical embryological models have explained how patterned structures are generated along the two principal axes of the limb: the proximodistal (shoulder to finger) and anteroposterior (thumb to little finger) axes. Over time, the genetic and molecular attributes of these patterning models have been discovered, while the role of growth in the patterning process has been only recently highlighted. In this review, we discuss these recent findings and propose how the various models of limb patterning can be reconciled.
发育中的肢体一直是研究脊椎动物模式形成的一个极具影响力的系统。过去，经典胚胎学模型解释了沿肢体两个主要轴如何生成有模式的结构：近远轴（肩部到手指）和前后轴（拇指到小指）。随着时间的推移，这些模式形成模型的遗传和分子特性已被发现，而生长在模式形成过程中的作用直到最近才受到关注。在这篇综述中，我们讨论这些最新发现，并提出肢体模式形成的各种模型如何能够相互协调。
